Stem cells in the trabecular meshwork: Present and future promises

M. J. Kelley; A. Y. Rose; K. E. Keller; H. Hessle; J. R. Samples; T. S. Acott

doi:10.1016/j.exer.2008.10.024

Stem cells in the trabecular meshwork: Present and future promises

M. J. Kelley, A. Y. Rose, K. E. Keller, H. Hessle, J. R. Samples, T. S. Acott

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

Original language	English (US)
Pages (from-to)	747-751
Number of pages	5
Journal	Experimental Eye Research
Volume	88
Issue number	4
DOIs	https://doi.org/10.1016/j.exer.2008.10.024
State	Published - Apr 30 2009

Keywords

glaucoma
progenitor cells
regeneration
stem cells
trabecular meshwork

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/j.exer.2008.10.024

Cite this

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title = "Stem cells in the trabecular meshwork: Present and future promises",

abstract = "Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.",

keywords = "glaucoma, progenitor cells, regeneration, stem cells, trabecular meshwork",

author = "Kelley, {M. J.} and Rose, {A. Y.} and Keller, {K. E.} and H. Hessle and Samples, {J. R.} and Acott, {T. S.}",

note = "Funding Information: The authors thank Genevieve Long, Ph.D., for editorial assistance. Support was provided by NIH EY003279, EY008247, EY010572, Research to Prevent Blindness, Prevent Blindness America, and the Gustavus and Louise Pfeiffer Research Foundation. ",

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T2 - Present and future promises

AU - Kelley, M. J.

AU - Rose, A. Y.

AU - Keller, K. E.

AU - Hessle, H.

AU - Samples, J. R.

AU - Acott, T. S.

N1 - Funding Information: The authors thank Genevieve Long, Ph.D., for editorial assistance. Support was provided by NIH EY003279, EY008247, EY010572, Research to Prevent Blindness, Prevent Blindness America, and the Gustavus and Louise Pfeiffer Research Foundation.

PY - 2009/4/30

Y1 - 2009/4/30

N2 - Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

AB - Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

KW - glaucoma

KW - progenitor cells

KW - regeneration

KW - stem cells

KW - trabecular meshwork

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Stem cells in the trabecular meshwork: Present and future promises

Abstract

Keywords

ASJC Scopus subject areas

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