Steroid-induced resolution of refractory pulmonary interstitial emphysema

Sidharth Mahapatra, Brian Scottoline

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Pulmonary interstitial emphysema (PIE) is a familiar complication of mechanical ventilation in premature infants. Its most severe form, marked by life-threatening respiratory and cardiovascular compromise, is a particularly vexing problem in neonatology. Treatment modalities rely on decubitus positioning and reduction of mean airway pressure, but refractory PIE is unresponsive to these maneuvers. Other options such as selective unilateral bronchial intubation, balloon catheter bronchial occlusion, selective lung volume reduction, and mechanical decompression each have clear limitations. In a patient with refractory, life-threatening PIE too unstable for other therapeutic modalities, we describe success with steroid therapy at a familiar dosing regimen.

Original languageEnglish (US)
Pages (from-to)4092-4095
Number of pages4
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number24
StatePublished - Dec 16 2016


  • Hydrocortisone
  • pneumothorax
  • pulmonary interstitial emphysema
  • respiratory distress syndrome
  • steroids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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