TY - JOUR
T1 - Stimuli-Responsive Biomaterials
T2 - Scaffolds for Stem Cell Control
AU - Gelmi, Amy
AU - Schutt, Carolyn E.
N1 - Publisher Copyright:
© 2020 The Authors. Published by Wiley-VCH GmbH
PY - 2021/1/6
Y1 - 2021/1/6
N2 - Stem cell fate is closely intertwined with microenvironmental and endogenous cues within the body. Recapitulating this dynamic environment ex vivo can be achieved through engineered biomaterials which can respond to exogenous stimulation (including light, electrical stimulation, ultrasound, and magnetic fields) to deliver temporal and spatial cues to stem cells. These stimuli-responsive biomaterials can be integrated into scaffolds to investigate stem cell response in vitro and in vivo, and offer many pathways of cellular manipulation: biochemical cues, scaffold property changes, drug release, mechanical stress, and electrical signaling. The aim of this review is to assess and discuss the current state of exogenous stimuli-responsive biomaterials, and their application in multipotent stem cell control. Future perspectives in utilizing these biomaterials for personalized tissue engineering and directing organoid models are also discussed.
AB - Stem cell fate is closely intertwined with microenvironmental and endogenous cues within the body. Recapitulating this dynamic environment ex vivo can be achieved through engineered biomaterials which can respond to exogenous stimulation (including light, electrical stimulation, ultrasound, and magnetic fields) to deliver temporal and spatial cues to stem cells. These stimuli-responsive biomaterials can be integrated into scaffolds to investigate stem cell response in vitro and in vivo, and offer many pathways of cellular manipulation: biochemical cues, scaffold property changes, drug release, mechanical stress, and electrical signaling. The aim of this review is to assess and discuss the current state of exogenous stimuli-responsive biomaterials, and their application in multipotent stem cell control. Future perspectives in utilizing these biomaterials for personalized tissue engineering and directing organoid models are also discussed.
KW - biomaterials
KW - electrical stimulation
KW - magnetic fields
KW - photostimulation
KW - stem cells
KW - stimuli-responsive materials
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85091680925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091680925&partnerID=8YFLogxK
U2 - 10.1002/adhm.202001125
DO - 10.1002/adhm.202001125
M3 - Review article
C2 - 32996270
AN - SCOPUS:85091680925
SN - 2192-2640
VL - 10
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 1
M1 - 2001125
ER -