Purpose of review: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4+ T cells, particularly in anatomical areas of low drug penetrability. Recent findings: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4+ T-cell compartment may also show promise in non-CD4+ T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4+ T-cell populations are being developed. Summary: Although reservoir validity in these non-CD4+ T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.
ASJC Scopus subject areas
- Infectious Diseases