Stress and immunity: Implications for viral disease and wound healing

Leigh A. Rozlog; Janice K. Kiecolt-Glaser; Phillip T. Marucha; John F. Sheridan; Ronald Glaser

doi:10.1902/jop.1999.70.7.786

Stress and immunity: Implications for viral disease and wound healing

Leigh A. Rozlog, Janice K. Kiecolt-Glaser, Phillip T. Marucha, John F. Sheridan, Ronald Glaser

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

Original language	English (US)
Pages (from-to)	786-792
Number of pages	7
Journal	Journal of periodontology
Volume	70
Issue number	7
DOIs	https://doi.org/10.1902/jop.1999.70.7.786
State	Published - Jul 1999
Externally published	Yes

Keywords

Immune response
Stress, psychological
Viral diseases/pathogenesis
Wound healing

ASJC Scopus subject areas

Periodontics

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10.1902/jop.1999.70.7.786

Cite this

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abstract = "It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.",

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author = "Rozlog, {Leigh A.} and Kiecolt-Glaser, {Janice K.} and Marucha, {Phillip T.} and Sheridan, {John F.} and Ronald Glaser",

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AU - Marucha, Phillip T.

AU - Sheridan, John F.

AU - Glaser, Ronald

PY - 1999/7

Y1 - 1999/7

N2 - It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

AB - It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

KW - Immune response

KW - Stress, psychological

KW - Viral diseases/pathogenesis

KW - Wound healing

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Stress and immunity: Implications for viral disease and wound healing

Abstract

Keywords

ASJC Scopus subject areas

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