Stress and immunity: Implications for viral disease and wound healing

Leigh A. Rozlog, Janice K. Kiecolt-Glaser, Phillip T. Marucha, John F. Sheridan, Ronald Glaser

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


It is now well established that psychological stress can downregulate the cellular immune response. Communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine, and immune systems. Stress disrupts the homeostasis of this network, which in turn, alters immune function. In this review, we discuss the role of stress in modulating cellular immune function and the potential health implications of this downregulation.

Original languageEnglish (US)
Pages (from-to)786-792
Number of pages7
JournalJournal of periodontology
Issue number7
StatePublished - Jul 1999
Externally publishedYes


  • Immune response
  • Stress, psychological
  • Viral diseases/pathogenesis
  • Wound healing

ASJC Scopus subject areas

  • Periodontics


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