TY - JOUR
T1 - Stress-Related Neuropeptides and Addictive Behaviors
T2 - Beyond the Usual Suspects
AU - Schank, Jesse R.
AU - Ryabinin, Andrey E.
AU - Giardino, William J.
AU - Ciccocioppo, Roberto
AU - Heilig, Markus
N1 - Funding Information:
The authors thank Dr. Yavin Shaham for important comments on this manuscript and Mrs. Karen Smith for bibliographic assistance. The work was in part supported by NIH grants AA01760 (A.E.R.), AA016647 (A.E.R.), AA019793 (A.E.R.), AA021023 (W.J.G.), AA014351 (R.C.), and AA017447 (R.C.).
PY - 2012/10/4
Y1 - 2012/10/4
N2 - Addictive disorders are chronic, relapsing conditions that cause extensive disease burden. Genetic factors partly account for susceptibility to addiction, but environmental factors such as stressful experiences and prolonged exposure of the brain to addictive drugs promote its development. Progression to addiction involves neuroadaptations within neurocircuitry that mediates stress responses and is influenced by several peptidergic neuromodulators. While corticotrophin releasing factor is the prototypic member of this class, recent work has identified several additional stress-related neuropeptides that play an important role in regulation of drug intake and relapse, including the urocortins, nociceptin, substance P, and neuropeptide S. Here, we review this emerging literature, discussing to what extent the properties of these neuromodulators are shared or distinct and considering their potential as drug targets.
AB - Addictive disorders are chronic, relapsing conditions that cause extensive disease burden. Genetic factors partly account for susceptibility to addiction, but environmental factors such as stressful experiences and prolonged exposure of the brain to addictive drugs promote its development. Progression to addiction involves neuroadaptations within neurocircuitry that mediates stress responses and is influenced by several peptidergic neuromodulators. While corticotrophin releasing factor is the prototypic member of this class, recent work has identified several additional stress-related neuropeptides that play an important role in regulation of drug intake and relapse, including the urocortins, nociceptin, substance P, and neuropeptide S. Here, we review this emerging literature, discussing to what extent the properties of these neuromodulators are shared or distinct and considering their potential as drug targets.
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U2 - 10.1016/j.neuron.2012.09.026
DO - 10.1016/j.neuron.2012.09.026
M3 - Review article
C2 - 23040815
AN - SCOPUS:84867137817
SN - 0896-6273
VL - 76
SP - 192
EP - 208
JO - Neuron
JF - Neuron
IS - 1
ER -