Stress-testing pelvic autosegmentation algorithms using anatomical edge cases

Aasheesh Kanwar, Brandon Merz, Cheryl Claunch, Shushan Rana, Arthur Hung, Reid F. Thompson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Commercial autosegmentation has entered clinical use, however real-world performance may suffer in certain cases. We aimed to assess the influence of anatomic variants on performance. We identified 112 prostate cancer patients with anatomic variations (edge cases). Pelvic anatomy was autosegmented using three commercial tools. To evaluate performance, Dice similarity coefficients, and mean surface and 95% Hausdorff distances were calculated versus clinician-delineated references. Deep learning autosegmentation outperformed atlas-based and model-based methods. However, edge case performance was lower versus the normal cohort (0.12 mean DSC reduction). Anatomic variation presents challenges to commercial autosegmentation.

Original languageEnglish (US)
Article number100413
JournalPhysics and Imaging in Radiation Oncology
StatePublished - Jan 2023


  • Anatomical variability
  • Autosegmentation
  • Deep learning
  • Edge case
  • Prostate cancer

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging


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