Structural and biophysical characterization of the interactions between the death domain of fas receptor and calmodulin

Timothy F. Fernandez, Alexandra B. Samal, Gregory J. Bedwell, Yabing Chen, Jamil S. Saad

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: Calmodulin (CaM) is recruited into the death-inducing signaling complex in cholangiocarcinoma cells. Results: CaM binds to FasDD in a 2:1 CaM:FasDD model. CaM antagonists abolish FasDD-CaM interactions. Conclusion: Data offer a structural basis for Fas-CaM interactions and mechanisms of inhibition. Significance: Elucidating the structural determinants of Fas-CaM interaction is critical to understanding the functional role of CaM in Fas-mediated apoptosis.

Original languageEnglish (US)
Pages (from-to)21898-21908
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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