TY - JOUR
T1 - Structure and mechanism of AMPA receptor — auxiliary protein complexes
AU - Chen, Shanshuang
AU - Gouaux, Eric
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Ionotropic glutamate receptors in vertebrates are composed of three major subtypes – AMPA, kainate, and NMDA receptors – and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor — auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization.
AB - Ionotropic glutamate receptors in vertebrates are composed of three major subtypes – AMPA, kainate, and NMDA receptors – and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor — auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization.
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U2 - 10.1016/j.sbi.2019.01.011
DO - 10.1016/j.sbi.2019.01.011
M3 - Review article
C2 - 30825796
AN - SCOPUS:85062023623
SN - 0959-440X
VL - 54
SP - 104
EP - 111
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -