Structure and regulation of calcium/calmodulin-dependent protein kinases

Thomas R. Soderling; James T. Stull

doi:10.1021/cr0002386

Structure and regulation of calcium/calmodulin-dependent protein kinases

Thomas R. Soderling, James T. Stull

Vollum Institute

Research output: Contribution to journal › Review article › peer-review

171 Scopus citations

Abstract

The structure and regulation of calcium\calmodulin-dependent protein kinases (CaM-K) were discussed. The CaM-K were activated and inhibited through phosphorylation by other protein kinases. The results showed that the cross-talk with other signalling pathways allowed the integration of Ca²⁺ signals with other signalling pathways to modulate the physiological output of the cell.

Original language	English (US)
Pages (from-to)	2341-2351
Number of pages	11
Journal	Chemical Reviews
Volume	101
Issue number	8
DOIs	https://doi.org/10.1021/cr0002386
State	Published - Aug 2001

ASJC Scopus subject areas

General Chemistry

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10.1021/cr0002386

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title = "Structure and regulation of calcium/calmodulin-dependent protein kinases",

abstract = "The structure and regulation of calcium\calmodulin-dependent protein kinases (CaM-K) were discussed. The CaM-K were activated and inhibited through phosphorylation by other protein kinases. The results showed that the cross-talk with other signalling pathways allowed the integration of Ca2+ signals with other signalling pathways to modulate the physiological output of the cell.",

author = "Soderling, {Thomas R.} and Stull, {James T.}",

year = "2001",

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AB - The structure and regulation of calcium\calmodulin-dependent protein kinases (CaM-K) were discussed. The CaM-K were activated and inhibited through phosphorylation by other protein kinases. The results showed that the cross-talk with other signalling pathways allowed the integration of Ca2+ signals with other signalling pathways to modulate the physiological output of the cell.

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Structure and regulation of calcium/calmodulin-dependent protein kinases

Abstract

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