Structure of the Cardiac Sodium Channel

Daohua Jiang; Hui Shi; Lige Tonggu; Tamer M. Gamal El-Din; Michael J. Lenaeus; Yan Zhao; Craig Yoshioka; Ning Zheng; William A. Catterall

doi:10.1016/j.cell.2019.11.041

Structure of the Cardiac Sodium Channel

Daohua Jiang, Hui Shi, Lige Tonggu, Tamer M. Gamal El-Din, Michael J. Lenaeus, Yan Zhao, Craig Yoshioka, Ning Zheng, William A. Catterall

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.

Original language	English (US)
Pages (from-to)	122-134.e10
Journal	Cell
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.11.041
State	Published - Jan 9 2020

Keywords

antiarrhytymic drugs
cryoelectron microscopy arrhythmia
fast inactivation
gating pore current
heart
sodium channel
sodium selectivity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2019.11.041

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title = "Structure of the Cardiac Sodium Channel",

abstract = "The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.",

keywords = "antiarrhytymic drugs, cryoelectron microscopy arrhythmia, fast inactivation, gating pore current, heart, sodium channel, sodium selectivity",

author = "Daohua Jiang and Hui Shi and Lige Tonggu and {Gamal El-Din}, {Tamer M.} and Lenaeus, {Michael J.} and Yan Zhao and Craig Yoshioka and Ning Zheng and Catterall, {William A.}",

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T1 - Structure of the Cardiac Sodium Channel

AU - Jiang, Daohua

AU - Shi, Hui

AU - Tonggu, Lige

AU - Gamal El-Din, Tamer M.

AU - Lenaeus, Michael J.

AU - Zhao, Yan

AU - Yoshioka, Craig

AU - Zheng, Ning

AU - Catterall, William A.

PY - 2020/1/9

Y1 - 2020/1/9

N2 - The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.

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KW - cryoelectron microscopy arrhythmia

KW - fast inactivation

KW - gating pore current

KW - heart

KW - sodium channel

KW - sodium selectivity

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Structure of the Cardiac Sodium Channel

Abstract

Keywords

ASJC Scopus subject areas

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