Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis

L. B. Flexner; R. H. Goodman

doi:10.1073/pnas.72.11.4660

Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis

L. B. Flexner, R. H. Goodman

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Abstract

The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

Original language	English (US)
Pages (from-to)	4660-4663
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	72
Issue number	11
DOIs	https://doi.org/10.1073/pnas.72.11.4660
State	Published - 1975
Externally published	Yes

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title = "Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis",

abstract = "The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.",

author = "Flexner, {L. B.} and Goodman, {R. H.}",

year = "1975",

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AB - The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

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Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis

Abstract

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