Subcellular trafficking and endocytic recycling of KATP channels

Natalie Samper, Timothy Cardozo, Mario Delmar, Show Ling Shyng, William A. Coetzee, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Hua Qian Yang

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Sarcolemmal/plasmalemmal ATP-sensitive K+ (KATP) channels have key roles in many cell types and tissues. Hundreds of studies have described how the KATP channel activity and ATP sensitivity can be regulated by changes in the cellular metabolic state, by receptor signaling pathways and by pharmacological interventions. These alterations in channel activity directly translate to alterations in cell or tissue function, that can range from modulating secretory responses, such as insulin release from pancreatic b-cells or neurotransmitters from neurons, to modulating contractile behavior of smooth muscle or cardiac cells to elicit alterations in blood flow or cardiac contractility. It is increasingly becoming apparent, however, that KATP channels are regulated beyond changes in their activity. Recent studies have highlighted that KATP channel surface expression is a tightly regulated process with similar implications in health and disease. The surface expression of KATP channels is finely balanced by several trafficking steps including synthesis, assembly, anterograde trafficking, membrane anchoring, endocytosis, endocytic recycling, and degradation. This review aims to summarize the physiological and pathophysiological implications of KATP channel trafficking and mechanisms that regulate KATP channel trafficking. A better understanding of this topic has potential to identify new approaches to develop therapeutically useful drugs to treat KATP channel-related diseases.

Original languageEnglish (US)
Pages (from-to)C1230-C1247
JournalAmerican Journal of Physiology - Cell Physiology
Issue number6
StatePublished - Jun 2022
Externally publishedYes


  • K channel
  • Kchannel
  • inward rectifier potassium channel
  • trafficking

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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