Abstract
Chronic administration of the norepinephrine (NE) reuptake inhibitor nisoxetine reduced the sensitivity of the NE receptor-coupled adenylate cyclase system in rat cortex. This subsensitivity, unlike that caused by desipramine (DMI), was not related to a reduction in specific β-adrenergic receptor binding. The specific serotonin reuptake inhibitor fluoxetine had no effect on either neurohormonal sensitivity or 3H-dihydroalprenolol binding.
Original language | English (US) |
---|---|
Pages (from-to) | 379-382 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 60 |
Issue number | 4 |
DOIs | |
State | Published - Dec 20 1979 |
Externally published | Yes |
Keywords
- Cyclic AMP
- Fluoxetine
- H-Dihydroalprenolol binding
- NE receptors
- Nisoxetine
- Subsensitivity
ASJC Scopus subject areas
- Pharmacology