16 Oxygen irradiation enhances cued fear memory in B6D2F1 mice

Jacob Raber, Tessa Marzulla, Amy Kronenberg, Mitchell S. Turker

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16 O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16 O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16 O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16 O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16 O ion exposure.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalLife Sciences in Space Research
StatePublished - Nov 2015


  • Amygdala
  • Contextual
  • Cued
  • Fear memory
  • Hippocampus
  • Irradiation

ASJC Scopus subject areas

  • Radiation
  • Ecology
  • Astronomy and Astrophysics
  • Agricultural and Biological Sciences (miscellaneous)
  • Health, Toxicology and Mutagenesis


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