Suppressor scanning at positions 177 and 236 in the Escherichia coli lactose/H+ cotransporter and stereotypical effects of acidic substituents that suggest a favored orientation of transmembrane segments relative to the lipid bilayer

S. C. King; S. Li

doi:10.1128/jb.180.10.2756-2758.1998

Suppressor scanning at positions 177 and 236 in the Escherichia coli lactose/H⁺ cotransporter and stereotypical effects of acidic substituents that suggest a favored orientation of transmembrane segments relative to the lipid bilayer

S. C. King, S. Li

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.

Original language	English (US)
Pages (from-to)	2756-2758
Number of pages	3
Journal	Journal of bacteriology
Volume	180
Issue number	10
DOIs	https://doi.org/10.1128/jb.180.10.2756-2758.1998
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/jb.180.10.2756-2758.1998

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Suppressor scanning at positions 177 and 236 in the Escherichia coli lactose/H⁺ cotransporter and stereotypical effects of acidic substituents that suggest a favored orientation of transmembrane segments relative to the lipid bilayer. / King, S. C.; Li, S.
In: Journal of bacteriology, Vol. 180, No. 10, 1998, p. 2756-2758.

Research output: Contribution to journal › Article › peer-review

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abstract = "Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.",

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