TY - CHAP
T1 - Synergistic sedation
T2 - Fatalforty DDI: Midazolam, clozapine, synergism and clozapine, sertraline, CYP2D6
AU - Hutchens, Michael P.
AU - Schipper, Paul
AU - Marcucci, Catherine
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2015. All rights reserved.
PY - 2015/9/15
Y1 - 2015/9/15
N2 - This case discusses a pharmacodynamic interaction between clozapine, midazolam, fentanyl, hydromorphone, and oxycodone resulting in central nervous system depression. It also discusses a pharmacokinetic interaction between clozapine and sertraline resulting in increased bioavailability of clozapine.
AB - This case discusses a pharmacodynamic interaction between clozapine, midazolam, fentanyl, hydromorphone, and oxycodone resulting in central nervous system depression. It also discusses a pharmacokinetic interaction between clozapine and sertraline resulting in increased bioavailability of clozapine.
UR - http://www.scopus.com/inward/record.url?scp=84955373349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955373349&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-7495-1_87
DO - 10.1007/978-1-4614-7495-1_87
M3 - Chapter
AN - SCOPUS:84955373349
SN - 9781461474944
SP - 405
EP - 407
BT - A Case Approach to Perioperative Drug-Drug Interactions
PB - Springer New York
ER -