Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.
|Original language||English (US)|
|Title of host publication||Immunological Mechanisms and Therapies in Brain Injuries and Stroke|
|Publisher||Springer New York|
|Number of pages||24|
|State||Published - Jan 1 2014|
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