Systemic immune responses after experimental stroke

Halina Offner, Patricia D. Hurn

Research output: Chapter in Book/Report/Conference proceedingChapter


Stroke-induced pathology involves biphasic induction of an early massive peripheral immune cell activation followed by delayed, progressive splenic apoptosis and consequent immunosuppression. In this chapter, we review key immunological aspects of stroke induction and immunosuppression in the context of an emerging concept called "brain-spleen injury cycling." Moreover, we discuss the contribution to stroke severity of immune cells, including T and B cells, regulatory IL-10 secreting B cells and the programmed death receptor/ligand inhibitory pathway. Finally, we propose two novel therapeutic approaches that may limit stroke pathology and ameliorate downstream immunosuppression.

Original languageEnglish (US)
Title of host publicationImmunological Mechanisms and Therapies in Brain Injuries and Stroke
PublisherSpringer New York
Number of pages24
ISBN (Electronic)9781461489153
ISBN (Print)9781461489146
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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