Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

P. Rada; G. P. Mark; E. Pothos; B. G. Hoebel

doi:10.1016/0028-3908(91)90145-2

Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

P. Rada, G. P. Mark, E. Pothos, B. G. Hoebel

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p < .01) while it increased DA (55%, p < .01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.

Original language	English (US)
Pages (from-to)	1133-1136
Number of pages	4
Journal	Neuropharmacology
Volume	30
Issue number	10
DOIs	https://doi.org/10.1016/0028-3908(91)90145-2
State	Published - Oct 1991
Externally published	Yes

Keywords

Acetycholine
Dopamine
Microdialysis
Morphine
Nucleus Accumbens
Rat

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(91)90145-2

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abstract = "Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p < .01) while it increased DA (55%, p < .01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.",

keywords = "Acetycholine, Dopamine, Microdialysis, Morphine, Nucleus Accumbens, Rat",

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AU - Rada, P.

AU - Mark, G. P.

AU - Pothos, E.

AU - Hoebel, B. G.

PY - 1991/10

Y1 - 1991/10

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AB - Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p < .01) while it increased DA (55%, p < .01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.

KW - Acetycholine

KW - Dopamine

KW - Microdialysis

KW - Morphine

KW - Nucleus Accumbens

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Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats

Abstract

Keywords

ASJC Scopus subject areas

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