Microdialysis was used to measure extracellular levels of acetylcholine (ACh) and dopamine (DA) simultaneously in the nucleus accumbens (NAC) of freely moving rats. Systemic injection of morphine (20 mg/kg) significantly decreased ACh (30%, p < .01) while it increased DA (55%, p < .01). The effects of morphine were eliminated by naloxone. The results comfirm that morphine increases DA and in addition, demonstrate an inhibitory influence of this opiate on extracellular levels of ACh in the NAC.
- Nucleus Accumbens
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience