Abstract
Upon recovery from the initial episode of experimental autoimmune encephalomyelitis (EAE), virtually all SJL mice develop relapsing/remitting episodes of disease. These relapses may occur due to the reactivation of memory T cells initially stimulated as part of the disease-inducing protocol or naïve T-cell populations stimulated by distinct encephalitogens derived from the inflammatory disease process (epitope spread). We have used encephalitogen-specific non-linear peptide octamers to modify the course of relapsing EAE (rEAE) in SJL mice immunized with an oliogodendrocyte-specific protein peptide (OSP 55-71). Our studies show that the peptide-octamers, which target the T cells stimulated by the priming encephalitogen, but not other candidate encephalitogens, prevent rEAE.
Original language | English (US) |
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Pages (from-to) | 74-81 |
Number of pages | 8 |
Journal | Journal of Neuroimmunology |
Volume | 260 |
Issue number | 1-2 |
DOIs | |
State | Published - 2013 |
Keywords
- Epitope spread
- Memory cells
- Non-linear peptide octamers
- Peptide immunotherapy
- Relapsing EAE
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology