Telemedical Diagnosis of Stage 4 and Stage 5 Retinopathy of Prematurity

Samir N. Patel, Ranjodh Singh, Karyn E. Jonas, Susan Ostmo, Mrinali P. Gupta, J. Peter Campbell, Michael Chiang, R. V.Paul Chan, Michael F. Chiang, Susan Ostmo, Kemal Sonmez, J. Peter Campbell, R. V.Paul Chan, Karyn Jonas, Jason Horowitz, Osode Coki, Cheryl Ann Eccles, Leora Sarna, Anton Orlin, Audina BerrocalCatherin Negron, Kimberly Drenser, Kristi Cumming, Tammy Osentoski, Tammy Check, Mary Zajechowski, Thomas Lee, Evan Kruger, Kathryn McGovern, Charles Simmons, Raghu Murthy, Sharon Galvis, Jerome Rotter, Ida Chen, Xiaohui Li, Kent Taylor, Kaye Roll, Jayashree Kalpathy-Cramer, Deniz Erdogmus, Stratis Ioannidis, Maria Ana Martinez-Castellanos, Samantha Salinas-Longoria, Rafael Romero, Andrea Arriola, Francisco Olguin-Manriquez, Miroslava Meraz-Gutierrez, Carlos M. Dulanto-Reinoso, Cristina Montero-Mendoza

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: To determine the accuracy of image-based diagnosis for stage 4 or worse retinopathy of prematurity (ROP) disease. Design: Prospective cohort study. Participants: We prospectively obtained data, from 8 major ROP centers, for 1220 eye examinations from 230 infants. Methods: An ophthalmologist at each center provided a clinical diagnosis using indirect ophthalmoscopy. Wide-angle retinal images (RetCam; Clarity Medical Systems, Pleasanton, CA) were then obtained, and these were independently read by 2 ROP experts using a web-based system for an image-based diagnosis. Main Outcome Measures: Sensitivity and specificity of image-based diagnosis from the ROP experts were calculated using the clinical diagnosis as the reference standard. Results: Of 1220 examinations, 28 (2%) had a clinical diagnosis of stage 4 or worse. Sensitivity and specificity for stage 4 or worse disease were 75% and 99% for expert 1, and 86% and 99% for expert 2. Sensitivity and specificity for the detection of stage 5 disease were 69% and 99% for both experts. Conclusions: There are inconsistencies in the accuracy of image-based diagnosis of stage 4 and stage 5 ROP when compared with the clinical diagnosis.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalOphthalmology Retina
Issue number1
StatePublished - 2018

ASJC Scopus subject areas

  • Ophthalmology


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