TY - JOUR
T1 - Terminal differentiation of myeloleukemic M1 cells induced by IL-6
T2 - Role of endogenous interferon
AU - Gothelf, Y.
AU - Raber, J.
AU - Chen, L.
AU - Schattner, A.
AU - Chebath, J.
AU - Revel, M.
PY - 1991
Y1 - 1991
N2 - During terminal differentiation of myeloleukemic M1 cells triggered by IL- 6, an induction of IFN-activated genes, such as IRF-1, class I MHC, and (2'- 5')-A synthetase, is observed. Antibodies to murine type I IFN, inhibit most (2'-5')-A synthetase induction but do not inhibit IL-6-induced growth-arrest and differentiation. IL-6 induction of (2'-5')-A synthetase subforms, however, differs from that of IFN. IL-6 in fact induces a cell surface form of (2'-5')-A synthetase that is not induced by IFN.
AB - During terminal differentiation of myeloleukemic M1 cells triggered by IL- 6, an induction of IFN-activated genes, such as IRF-1, class I MHC, and (2'- 5')-A synthetase, is observed. Antibodies to murine type I IFN, inhibit most (2'-5')-A synthetase induction but do not inhibit IL-6-induced growth-arrest and differentiation. IL-6 induction of (2'-5')-A synthetase subforms, however, differs from that of IFN. IL-6 in fact induces a cell surface form of (2'-5')-A synthetase that is not induced by IFN.
UR - http://www.scopus.com/inward/record.url?scp=0025751591&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025751591&partnerID=8YFLogxK
M3 - Article
C2 - 1768740
AN - SCOPUS:0025751591
SN - 0277-6766
VL - 10
SP - 369
EP - 375
JO - Lymphokine and Cytokine Research
JF - Lymphokine and Cytokine Research
IS - 5
ER -