Tetrahydrofuran, tetrahydropyran and oxepane formation by cobaloxime π-cation cyclizations

Lana M. Grubb, Katherine A. Brown, Bruce P. Branchaud

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Studies are reported on the cyclization of (ω-hydroxy-β-hydroxyalkyl)cobaloximes (1, 2 and 3) to form 5,6 and 7-membered ring cyclic ethers (4, 5 and 6). Reversible cyclization and eventual irreversible alkene decomplexation (to form 7, 8 and 9) varied as a function of ring size. The practical consequence is that cyclizations to form 5 and 6 membered rings are feasible whereas formation of a 7 membered ring is not.

Original languageEnglish (US)
Pages (from-to)3447-3448
Number of pages2
JournalTetrahedron Letters
Issue number21
StatePublished - May 21 1998
Externally publishedYes


  • Carbonium ions
  • Cobalt and compounds
  • Cyclization
  • Ethers

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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