The advantages and disadvantages of novel contrast agent types for fluorescence guided surgery

Connor W. Barth, Summer L. Gibbs

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Rapid expansion in the field of fluorescence guided surgery (FGS) has yielded a wide range of contrast agent types under development with diverse characteristics. Currently, 105 active or completed clinical trials are registered in studying 39 unique novel FGS contrast agents. For these 39 contrast agents, there exists 6 distinct classes or types of probes: nanoparticle, antibody, protein, affibody, peptide, and small molecule. This diversity yields unique advantages and disadvantages among each type of contrast agent, which change throughout the various stages of development and clinical translation. In this review, we outline the relevant advantages and disadvantages for each type of FGS contrast agent at each stage of development. As the field continues to progress and expand, this diversity in FGS contrast agent type and their respective unique characteristics will enable broad applicability to shift the surgical paradigm and improve outcomes for patients across all surgical specialties.

Original languageEnglish (US)
Title of host publicationMolecular-Guided Surgery
Subtitle of host publicationMolecules, Devices, and Applications VIII
EditorsSylvain Gioux, Summer L. Gibbs, Brian W. Pogue
ISBN (Electronic)9781510647572
StatePublished - 2022
EventMolecular-Guided Surgery: Molecules, Devices, and Applications VIII 2022 - Virtual, Onlline
Duration: Feb 20 2022Feb 24 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications VIII 2022
CityVirtual, Onlline


  • Fluorescence
  • clinical development
  • clinical trial
  • contrast agent
  • image-guided surgery
  • near-infrared fluorescence
  • review

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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