TY - JOUR
T1 - The appearance of stippled retinal pigment epithelial detachments
T2 - A sign of occult choroidal neovascularization in age-related macular degeneration
AU - Frederick, Albert R.
AU - Morley, Michael G.
AU - Topping, Trexler M.
AU - Peterson, Timothy J.
AU - Wilson, David J.
PY - 1993
Y1 - 1993
N2 - The clinical source of 62 eyes that had been coded for macular degeneration and fi- brovascular retinal pigment epithelial (RPE) detachment on fluorescein angiography was reviewed; 17 eyes had signs of a choroidal neovas- cular membrane (CNVM) at initial examination, and 30 eyes developed a definite CNVM during follow-up examination. Thus, 47 of the 62 eyes (76%) developed a CNVM in association with fibrovascular RPE detachments. Features of fi- brovascular RPE detachments include: 1) focal, tiny hyperfluorescent spots at the level of the RPE arising in the mid and late frames of the angiogram, which do not correspond to drusen or foci of depigmentation (stippled hyperfluorescence); 2) intensification of these spots in the later stages of the angiogram; 3) slight enlargement of the spots in the late frames of the angiogram; 4) occasional presence of scant overlying subretinal fluid; and 5) minimal elevation of the RPE. Fibrovascular RPE detachments appear to be a distinct form of an RPE detachment. It is concluded that this sign is associated with a high risk of developing a frank CNVM and is thus a reliable indicator of occult neovascularization.
AB - The clinical source of 62 eyes that had been coded for macular degeneration and fi- brovascular retinal pigment epithelial (RPE) detachment on fluorescein angiography was reviewed; 17 eyes had signs of a choroidal neovas- cular membrane (CNVM) at initial examination, and 30 eyes developed a definite CNVM during follow-up examination. Thus, 47 of the 62 eyes (76%) developed a CNVM in association with fibrovascular RPE detachments. Features of fi- brovascular RPE detachments include: 1) focal, tiny hyperfluorescent spots at the level of the RPE arising in the mid and late frames of the angiogram, which do not correspond to drusen or foci of depigmentation (stippled hyperfluorescence); 2) intensification of these spots in the later stages of the angiogram; 3) slight enlargement of the spots in the late frames of the angiogram; 4) occasional presence of scant overlying subretinal fluid; and 5) minimal elevation of the RPE. Fibrovascular RPE detachments appear to be a distinct form of an RPE detachment. It is concluded that this sign is associated with a high risk of developing a frank CNVM and is thus a reliable indicator of occult neovascularization.
KW - Age-Related macular degeneration
KW - Fibrovascular retinal pigment epithelium detachment
KW - Fluorescein angiography
KW - Neovascular membrane
KW - Occult choroidal neovascular membrane
KW - Retinal pigment epithelial detachment
KW - Stippled hyperfluorescence
UR - http://www.scopus.com/inward/record.url?scp=0027477417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027477417&partnerID=8YFLogxK
U2 - 10.1097/00006982-199313010-00002
DO - 10.1097/00006982-199313010-00002
M3 - Article
C2 - 7681606
AN - SCOPUS:0027477417
SN - 0275-004X
VL - 13
SP - 3
EP - 7
JO - Retina
JF - Retina
IS - 1
ER -