The broad spectrum of inherited growth hormone insensitivity syndrome

Linda B. Johnston; Katie A. Woods; Stephen J. Rose; Adrian J.L. Clark; Martin O. Savage

doi:10.1016/S1043-2760(98)00062-9

The broad spectrum of inherited growth hormone insensitivity syndrome

Linda B. Johnston, Katie A. Woods, Stephen J. Rose, Adrian J.L. Clark, Martin O. Savage

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Growth hormone (GH) insensitivity syndrome (GHIS) results in severe short stature and metabolic disturbances, but when this disorder is studied in more detail it is clear that there is marked clinical and biochemical heterogeneity. Many genetic defects of the GH receptor have been reported in inherited GHIS, but it now seems likely that some cases might be the result of defects of other genes or of links in the post-receptor cascade.

Original language	English (US)
Pages (from-to)	228-232
Number of pages	5
Journal	Trends in Endocrinology and Metabolism
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/S1043-2760(98)00062-9
State	Published - Aug 1 1998
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/S1043-2760(98)00062-9

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title = "The broad spectrum of inherited growth hormone insensitivity syndrome",

abstract = "Growth hormone (GH) insensitivity syndrome (GHIS) results in severe short stature and metabolic disturbances, but when this disorder is studied in more detail it is clear that there is marked clinical and biochemical heterogeneity. Many genetic defects of the GH receptor have been reported in inherited GHIS, but it now seems likely that some cases might be the result of defects of other genes or of links in the post-receptor cascade.",

author = "Johnston, {Linda B.} and Woods, {Katie A.} and Rose, {Stephen J.} and Clark, {Adrian J.L.} and Savage, {Martin O.}",

note = "Funding Information: We are grateful to Pharmacia and Upjohn, Stockholm, Sweden for support in the implementation of these studies and to Wellbeing for funding Dr L.B. Johnston. ",

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T1 - The broad spectrum of inherited growth hormone insensitivity syndrome

AU - Johnston, Linda B.

AU - Woods, Katie A.

AU - Rose, Stephen J.

AU - Clark, Adrian J.L.

AU - Savage, Martin O.

N1 - Funding Information: We are grateful to Pharmacia and Upjohn, Stockholm, Sweden for support in the implementation of these studies and to Wellbeing for funding Dr L.B. Johnston.

PY - 1998/8/1

Y1 - 1998/8/1

N2 - Growth hormone (GH) insensitivity syndrome (GHIS) results in severe short stature and metabolic disturbances, but when this disorder is studied in more detail it is clear that there is marked clinical and biochemical heterogeneity. Many genetic defects of the GH receptor have been reported in inherited GHIS, but it now seems likely that some cases might be the result of defects of other genes or of links in the post-receptor cascade.

AB - Growth hormone (GH) insensitivity syndrome (GHIS) results in severe short stature and metabolic disturbances, but when this disorder is studied in more detail it is clear that there is marked clinical and biochemical heterogeneity. Many genetic defects of the GH receptor have been reported in inherited GHIS, but it now seems likely that some cases might be the result of defects of other genes or of links in the post-receptor cascade.

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JO - Trends in Endocrinology and Metabolism

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The broad spectrum of inherited growth hormone insensitivity syndrome

Abstract

ASJC Scopus subject areas

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