TY - JOUR
T1 - The changing spectrum of hypertension in premature infants
AU - Farnbach, K.
AU - Iragorri, S.
AU - Al-Uzri, A.
AU - Rozansky, D.
AU - Forbush, R.
AU - Jenkins, R.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16% as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.
AB - Objective: The objective is to document changes in the etiologic spectrum of hypertension in premature infants. Study design: We reviewed all cases of systemic hypertension (HTN) in premature infants at two centers over 8 years. Infants were sorted into categorical groups as described in 2012 by Flynn. Analyses included frequency of diagnosis, timecourse of HTN, and diagnostics. Phthalate exposure via intravenous fluid and respiratory equipment was compared among groups and centers. Results: One hundred and twenty-nine infants having 130 episodes of HTN met the inclusion criteria. Sixty-five percent of cases were classified as pulmonary and 16% as miscellaneous. Plasma renin activity (PRA) was undetectable or <11 ng/mL/h in almost all hypertensive infants. Cases categorized as Pulmonary, medications/intoxications, and miscellaneous presented near 40 weeks postmenstrual age, with low PRA and large phthalate exposures. Conclusions: High PRA HTN has been replaced by low PRA in most cases, and may be due to phthalate exposure.
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U2 - 10.1038/s41372-019-0457-z
DO - 10.1038/s41372-019-0457-z
M3 - Article
C2 - 31388120
AN - SCOPUS:85070307688
SN - 0743-8346
VL - 39
SP - 1528
EP - 1534
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -