The effect of plasminogen activator inhibitor type 1 on apoptosis

David J. Schneider, Yabing Chen, Burton E. Sobel

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Plasminogen activator inhibitor type-1 (PAI-1), an inhibitor of plasminogen activators, inhibits formation of plasmin and plasmin-mediated proteolysis. Apoptosis, or programmed cell death, is a potentially important phenomenon in mediating overall cell death. This review focuses on the influence of PAI-1 on apoptosis. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. Mechanisms by which PAI-1 may render a cell resistant to apoptosis include its ability to inhibit generation of plasmin,its ability to inhibit caspase 3, and its ability to inhibit cell adhesion mediated by vitronectin. Inhibition of caspase 3 by PAI-1 may divert intracellular signalling from induction of apoptosis to induction of proliferation.

Original languageEnglish (US)
Pages (from-to)1037-1040
Number of pages4
JournalThrombosis and Haemostasis
Volume100
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Plasminogen activator inhibitor
  • Vascular remodelling

ASJC Scopus subject areas

  • Hematology

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