Abstract
Plasminogen activator inhibitor type-1 (PAI-1), an inhibitor of plasminogen activators, inhibits formation of plasmin and plasmin-mediated proteolysis. Apoptosis, or programmed cell death, is a potentially important phenomenon in mediating overall cell death. This review focuses on the influence of PAI-1 on apoptosis. Greater expression of PAI-1 has been associated with increased survival of cells and resistance to apoptosis. PAI-1 appears to influence apoptosis by decreasing cell adhesion (anoikis) as well as its effect on intracellular signaling. Mechanisms by which PAI-1 may render a cell resistant to apoptosis include its ability to inhibit generation of plasmin,its ability to inhibit caspase 3, and its ability to inhibit cell adhesion mediated by vitronectin. Inhibition of caspase 3 by PAI-1 may divert intracellular signalling from induction of apoptosis to induction of proliferation.
Original language | English (US) |
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Pages (from-to) | 1037-1040 |
Number of pages | 4 |
Journal | Thrombosis and Haemostasis |
Volume | 100 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2008 |
Externally published | Yes |
Keywords
- Apoptosis
- Cancer
- Plasminogen activator inhibitor
- Vascular remodelling
ASJC Scopus subject areas
- Hematology