The effects of alcohol withdrawal and acute doses of alcohol on the acid-base balance in mice and rats

M. A. Mitchell; J. K. Belknap

doi:10.1016/0376-8716(82)90031-X

The effects of alcohol withdrawal and acute doses of alcohol on the acid-base balance in mice and rats

M. A. Mitchell
, J. K. Belknap

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

While respiratory alkalosis has been reported to occur in human alcoholics during the withdrawal period, and may causally contribute to the expression of the withdrawal syndrome, we found no evidence of this in either alcohol physically-dependent mice (DBA/2J) or rats (Sprague-Dawley) as reflected in blood pH, plasma pCO₂, or intracellular brain pH relative to pair-fed control (no alcohol) animals. The inhalation of atmospheres high in CO₂ (5% and 15%), which would be expected to reverse a respiratory alkalotic state, had no effect on the expression of the withdrawal syndrome in alcohol-dependent mice. These results indicate that a withdrawal syndrome of considerable intensity can develop in mice and rats in the absence of an alkalotic state.

Original language	English (US)
Pages (from-to)	283-294
Number of pages	12
Journal	Drug and Alcohol Dependence
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0376-8716(82)90031-X
State	Published - Dec 1982
Externally published	Yes

Funding

The work was supported by NIDA BRSG grant awarded to J. K. Belknap.

Funders	Funder number
NIDA BRSG
National Institute on Drug Abuse	R01DA002723

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0376-8716(82)90031-X

Cite this

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title = "The effects of alcohol withdrawal and acute doses of alcohol on the acid-base balance in mice and rats",

abstract = "While respiratory alkalosis has been reported to occur in human alcoholics during the withdrawal period, and may causally contribute to the expression of the withdrawal syndrome, we found no evidence of this in either alcohol physically-dependent mice (DBA/2J) or rats (Sprague-Dawley) as reflected in blood pH, plasma pCO2, or intracellular brain pH relative to pair-fed control (no alcohol) animals. The inhalation of atmospheres high in CO2 (5\% and 15\%), which would be expected to reverse a respiratory alkalotic state, had no effect on the expression of the withdrawal syndrome in alcohol-dependent mice. These results indicate that a withdrawal syndrome of considerable intensity can develop in mice and rats in the absence of an alkalotic state.",

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T1 - The effects of alcohol withdrawal and acute doses of alcohol on the acid-base balance in mice and rats

AU - Mitchell, M. A.

AU - Belknap, J. K.

N1 - Funding Information: The work was supported by NIDA BRSG grant awarded to J. K. Belknap.

PY - 1982/12

Y1 - 1982/12

N2 - While respiratory alkalosis has been reported to occur in human alcoholics during the withdrawal period, and may causally contribute to the expression of the withdrawal syndrome, we found no evidence of this in either alcohol physically-dependent mice (DBA/2J) or rats (Sprague-Dawley) as reflected in blood pH, plasma pCO2, or intracellular brain pH relative to pair-fed control (no alcohol) animals. The inhalation of atmospheres high in CO2 (5% and 15%), which would be expected to reverse a respiratory alkalotic state, had no effect on the expression of the withdrawal syndrome in alcohol-dependent mice. These results indicate that a withdrawal syndrome of considerable intensity can develop in mice and rats in the absence of an alkalotic state.

AB - While respiratory alkalosis has been reported to occur in human alcoholics during the withdrawal period, and may causally contribute to the expression of the withdrawal syndrome, we found no evidence of this in either alcohol physically-dependent mice (DBA/2J) or rats (Sprague-Dawley) as reflected in blood pH, plasma pCO2, or intracellular brain pH relative to pair-fed control (no alcohol) animals. The inhalation of atmospheres high in CO2 (5% and 15%), which would be expected to reverse a respiratory alkalotic state, had no effect on the expression of the withdrawal syndrome in alcohol-dependent mice. These results indicate that a withdrawal syndrome of considerable intensity can develop in mice and rats in the absence of an alkalotic state.

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The effects of alcohol withdrawal and acute doses of alcohol on the acid-base balance in mice and rats

Abstract

Funding

ASJC Scopus subject areas

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