TY - JOUR
T1 - The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta
AU - Rhon-Calderon, Eric A.
AU - Vrooman, Lisa A.
AU - Riesche, Laren
AU - Bartolomei, Marisa S.
N1 - Funding Information:
This work was supported by the National Institute of Health (NIH) HD092266 , HD068157 , F32HD089623 (L.A.V.) and the National Institute of Nursing Research/NIH T32NR007100 (L.R.). Funding sources had no role in the opinions expressed in this review.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental function. Disturbances that occur during the establishment and maintenance of imprinting could compromise the placenta and fetus, and ultimately, offspring health. Assisted Reproductive Technologies (ART) have been widely used to overcome infertility, however experimental studies have shown that ART procedures affect placentation and the expression of imprinted genes. Here we briefly review the role of imprinted genes in placental development and the evidence from mouse and human studies suggesting ART disrupts imprinted gene regulation in the placenta.
AB - The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental function. Disturbances that occur during the establishment and maintenance of imprinting could compromise the placenta and fetus, and ultimately, offspring health. Assisted Reproductive Technologies (ART) have been widely used to overcome infertility, however experimental studies have shown that ART procedures affect placentation and the expression of imprinted genes. Here we briefly review the role of imprinted genes in placental development and the evidence from mouse and human studies suggesting ART disrupts imprinted gene regulation in the placenta.
KW - Assisted reproductive technologies
KW - Imprinted genes
KW - In vitro fertilization
KW - Placenta
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U2 - 10.1016/j.placenta.2019.02.013
DO - 10.1016/j.placenta.2019.02.013
M3 - Review article
C2 - 30871810
AN - SCOPUS:85062666486
SN - 0143-4004
VL - 84
SP - 37
EP - 43
JO - Placenta
JF - Placenta
ER -