The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat

Kim A. Neve; John F. Marshall

doi:10.1016/0304-3940(84)90202-7

The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat

Kim A. Neve, John F. Marshall

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [³H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.

Original language	English (US)
Pages (from-to)	77-83
Number of pages	7
Journal	Neuroscience Letters
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(84)90202-7
State	Published - Apr 20 1984
Externally published	Yes

Keywords

[H]spiroperidol
denervation
dopamine receptors
haloperidol
neostriatum
rat
receptor proliferation
supersensitivity

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(84)90202-7

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title = "The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat",

abstract = "The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [3H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.",

keywords = "[H]spiroperidol, denervation, dopamine receptors, haloperidol, neostriatum, rat, receptor proliferation, supersensitivity",

author = "Neve, {Kim A.} and Marshall, {John F.}",

note = "Funding Information: Supportedb y PHS Grant NS 20122a nd NSF Grant 82-08656to J.F.M.K.A.N. was supportedb y PHS predoctorafle llowshipM H 08915.",

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language = "English (US)",

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T1 - The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat

AU - Neve, Kim A.

AU - Marshall, John F.

N1 - Funding Information: Supportedb y PHS Grant NS 20122a nd NSF Grant 82-08656to J.F.M.K.A.N. was supportedb y PHS predoctorafle llowshipM H 08915.

PY - 1984/4/20

Y1 - 1984/4/20

N2 - The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [3H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.

AB - The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [3H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.

KW - [H]spiroperidol

KW - denervation

KW - dopamine receptors

KW - haloperidol

KW - neostriatum

KW - rat

KW - receptor proliferation

KW - supersensitivity

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VL - 46

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat

Abstract

Keywords

ASJC Scopus subject areas

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