TY - JOUR
T1 - The effects of mitral annuloplasty rings on mitral valve complex 3-D geometry during acute left ventricular ischemia
AU - Lai, David T.
AU - Timek, Tomasz A.
AU - Tibayan, Frederick A.
AU - Green, G. Randall
AU - Daughters, George T.
AU - Liang, David
AU - Ingels, Neil B.
AU - Miller, D. Craig
N1 - Funding Information:
Supported by grants HL-29589 and HL-67025 from the National Heart, Lung, and Blood Institute and accomplished during the tenure of a fellowship from the American Heart Association, Western States Affiliate, awarded to Doctor Lai. Doctors Green, Timek and Tibayan were supported by NHLBI Individual Research Service Awards HL-09569, HL-10452, and HL-67563; Doctors Green, Timek, and Lai were Carl and Leah McConnell Cardiovascular Surgical Research Fellows. Doctor Timek was a recipient of Thoracic Surgery Education and Research Foundation Fellowship Awards. We appreciate the technical assistance provided by Mary K. Zasio, B.A., Carol W. Mead, B.A., and Erin M. Schultz, B.S. We acknowledge and thank Julie R. Glasson, M.D. for her earlier work on these animals in our laboratory.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Objective: Annuloplasty rings are used to treat ischemic mitral regurgitation (IMR), but their exact effects on 3-D geometry of the overall mitral valve complex during acute left ventricular (LV) ischemia remain unknown. Methods: Radiopaque markers were sutured to the mitral leaflet edges, annulus, papillary muscle tips, and ventricle in three groups of sheep. One group served as control (n=5), and the others underwent Duran (n=6) or Physio (n=5) ring annuloplasty. One week later, 3-D marker coordinates at end-systole were obtained before and during balloon occlusion of the circumflex artery. Results: In all control animals, acute LV ischemia was associated with: (i) septal-lateral separation of the leaflet edges, which was predicted by lateral displacement of the lateral annulus during septal-lateral mitral annular dilatation; (ii) apical restriction of the posterior leaflet edge, which was predicted by displacement of the lateral annulus away from the non-ischemic anterior papillary muscle; (iii) displacement of the posterior papillary muscle, which was not predictive of either septal-lateral leaflet separation or leaflet restriction; and (iv) mitral regurgitation. In the Duran group during ischemia, the posterior leaflet edge shifted posteriorly due to posterior movement of the lateral annulus, but no IMR occurred. In the Physio group during ischemia, neither the posterior leaflet edge nor the lateral annulus changed positions, and there was no IMR. In both the Duran and Physio groups, displacement of the posterior papillary muscle did not lead to IMR. Conclusions: Either annuloplasty ring prevented the perturbations of mitral leaflet and annular - but not papillary muscle tip - 3-D geometry during acute LV ischemia. By fixing the septal-lateral annular dimension and preventing lateral displacement of the lateral annulus, annuloplasty rings prevented systolic septal-lateral leaflet separation and posterior leaflet restriction, and no acute IMR occurred. The flexible ring allowed posterior displacement of the posterior leaflet edge and the lateral annulus, which was not observed with a semi-rigid ring.
AB - Objective: Annuloplasty rings are used to treat ischemic mitral regurgitation (IMR), but their exact effects on 3-D geometry of the overall mitral valve complex during acute left ventricular (LV) ischemia remain unknown. Methods: Radiopaque markers were sutured to the mitral leaflet edges, annulus, papillary muscle tips, and ventricle in three groups of sheep. One group served as control (n=5), and the others underwent Duran (n=6) or Physio (n=5) ring annuloplasty. One week later, 3-D marker coordinates at end-systole were obtained before and during balloon occlusion of the circumflex artery. Results: In all control animals, acute LV ischemia was associated with: (i) septal-lateral separation of the leaflet edges, which was predicted by lateral displacement of the lateral annulus during septal-lateral mitral annular dilatation; (ii) apical restriction of the posterior leaflet edge, which was predicted by displacement of the lateral annulus away from the non-ischemic anterior papillary muscle; (iii) displacement of the posterior papillary muscle, which was not predictive of either septal-lateral leaflet separation or leaflet restriction; and (iv) mitral regurgitation. In the Duran group during ischemia, the posterior leaflet edge shifted posteriorly due to posterior movement of the lateral annulus, but no IMR occurred. In the Physio group during ischemia, neither the posterior leaflet edge nor the lateral annulus changed positions, and there was no IMR. In both the Duran and Physio groups, displacement of the posterior papillary muscle did not lead to IMR. Conclusions: Either annuloplasty ring prevented the perturbations of mitral leaflet and annular - but not papillary muscle tip - 3-D geometry during acute LV ischemia. By fixing the septal-lateral annular dimension and preventing lateral displacement of the lateral annulus, annuloplasty rings prevented systolic septal-lateral leaflet separation and posterior leaflet restriction, and no acute IMR occurred. The flexible ring allowed posterior displacement of the posterior leaflet edge and the lateral annulus, which was not observed with a semi-rigid ring.
KW - Acute left ventricular ischemia
KW - Annuloplasty rings
KW - Ischemic mitral regurgitation
KW - Mitral valve
KW - Three-dimensional mitral geometry
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U2 - 10.1016/S1010-7940(02)00530-4
DO - 10.1016/S1010-7940(02)00530-4
M3 - Article
C2 - 12414050
AN - SCOPUS:0036843591
SN - 1010-7940
VL - 22
SP - 808
EP - 816
JO - European Journal of Cardio-Thoracic Surgery
JF - European Journal of Cardio-Thoracic Surgery
IS - 5
ER -