The emerging role of lysophosphatidic acid in cancer

Gordon B. Mills, Wouter H. Moolenaar

Research output: Contribution to journalReview articlepeer-review

373 Scopus citations


The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

Original languageEnglish (US)
Pages (from-to)582-591
Number of pages10
JournalNature Reviews Cancer
Issue number8
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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