TY - JOUR
T1 - The emerging role of lysophosphatidic acid in cancer
AU - Mills, Gordon B.
AU - Moolenaar, Wouter H.
N1 - Funding Information:
We would like to thank E. Goetzl (University of California, San Fransisco) as well as members of our laboratories for allowing us to share unpublished data. This work is supported by grants from the National Cancer Institute (USA), Department of Defense (USA) and the Netherlands Cancer Institute (Holland).
PY - 2003/8
Y1 - 2003/8
N2 - The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
AB - The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=0042887042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042887042&partnerID=8YFLogxK
U2 - 10.1038/nrc1143
DO - 10.1038/nrc1143
M3 - Review article
C2 - 12894246
AN - SCOPUS:0042887042
SN - 1474-175X
VL - 3
SP - 582
EP - 591
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -