@inbook{3f6de52d20874907acda2a1d7d2b717c,
title = "The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors",
abstract = "The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.",
keywords = "Adhesion G protein, Cancer, Coupled receptor, Development, Immunology, Mechanosensation, Neurobiology, Signal transduction, Structural biology",
author = "Morgan, {Rory K.} and Anderson, {Garret R.} and Demet Ara{\c c} and Gabriela Aust and Nariman Balenga and Antony Boucard and Bridges, {James P.} and Engel, {Felix B.} and Formstone, {Caroline J.} and Glitsch, {Maike D.} and Gray, {Ryan S.} and Hall, {Randy A.} and Hsiao, {Cheng Chih} and Kim, {Hee Yong} and Knierim, {Alexander B.} and Kusuluri, {Deva Krupakar} and Katherine Leon and Ines Liebscher and Xianhua Piao and Simone Pr{\"o}mel and Nicole Scholz and Swati Srivastava and Doreen Thor and Tolias, {Kimberley F.} and Ushkaryov, {Yuri A.} and Mario Vallon and {Van Meir}, {Erwin G.} and Benoit Vanhollebeke and Uwe Wolfrum and Wright, {Kevin M.} and Monk, {Kelly R.} and Amit Mogha",
note = "Publisher Copyright: {\textcopyright} 2019 New York Academy of Sciences.",
year = "2019",
doi = "10.1111/nyas.14094",
language = "English (US)",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
number = "1",
pages = "5--25",
booktitle = "Annals of the New York Academy of Sciences",
edition = "1",
}