@inbook{3f6de52d20874907acda2a1d7d2b717c,
title = "The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors",
abstract = "The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.",
keywords = "Adhesion G protein, Cancer, Coupled receptor, Development, Immunology, Mechanosensation, Neurobiology, Signal transduction, Structural biology",
author = "Morgan, {Rory K.} and Anderson, {Garret R.} and Demet Ara{\c c} and Gabriela Aust and Nariman Balenga and Antony Boucard and Bridges, {James P.} and Engel, {Felix B.} and Formstone, {Caroline J.} and Glitsch, {Maike D.} and Gray, {Ryan S.} and Hall, {Randy A.} and Hsiao, {Cheng Chih} and Kim, {Hee Yong} and Knierim, {Alexander B.} and Kusuluri, {Deva Krupakar} and Katherine Leon and Ines Liebscher and Xianhua Piao and Simone Pr{\"o}mel and Nicole Scholz and Swati Srivastava and Doreen Thor and Tolias, {Kimberley F.} and Ushkaryov, {Yuri A.} and Mario Vallon and {Van Meir}, {Erwin G.} and Benoit Vanhollebeke and Uwe Wolfrum and Wright, {Kevin M.} and Monk, {Kelly R.} and Amit Mogha",
note = "Funding Information: All workshop participants are deeply grateful to Bobbi Chamberlain for her unparalleled organizational efforts. For financial support of the meeting, we thank Oregon Health & Science University (OHSU), the Vollum Institute at OHSU, The University of Illinois at Chicago, The Rudolf Sch{\"o}nheimer Institute of Biochemistry, Tecniplast, Union Biometrica, and Zeiss for their generous contributions. We thank JoAnn Trejo (UCSD) and Michael Bruchas (University of Washington) for outstanding keynote lectures. Finally, we acknowledge our colleagues who presented unpublished work not included in this meeting report, and the presenters of lightning talks and poster presentations. Publisher Copyright: {\textcopyright} 2019 New York Academy of Sciences.",
year = "2019",
doi = "10.1111/nyas.14094",
language = "English (US)",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
number = "1",
pages = "5--25",
booktitle = "Annals of the New York Academy of Sciences",
edition = "1",
}