TY - JOUR
T1 - The eyes of embryos with chromosome abnormalities
AU - Howard, Rufus O.
AU - Boué, Joelle
AU - Deluchat, Christiane
AU - Albert, Daniel M.
AU - Lahav, Moshe
N1 - Funding Information:
From the Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, and the Laboratoire de la S.E.S.E.P. (I.N.S.E.R.M. U. 73), Chateau de Longchamp, Paris, France. This study was supported in part by Public Health Service research grants EY-53332 and EY-00108 from the National Eye Institute, and by the Institut National de la Sante et de la Recherches Scientifique et Technique.
PY - 1974/8
Y1 - 1974/8
N2 - Eyes from 19 human embryos with proved chromosomal abnormalities were examined histopathologically. The chromosomal aberrations included monosomy X, B trisomy, C trisomy (10 trisomy), D trisomy, G trisomy, and triploidy. Some ocular abnormalities were identified which represented primarily a retardation of development, while other findings represented dysgenesis of ocular structures. The spectrum of ocular abnormalities included cyclopia, microphthalmia, cataract, staphyloma of the optic nerve, retinal dysplasia, and subluxation of the lens. Abnormalities of ocular development were thus seen in structures derived from surface ectoderm, neural ectoderm, and mesoderm in association with an abnormal karyotype.
AB - Eyes from 19 human embryos with proved chromosomal abnormalities were examined histopathologically. The chromosomal aberrations included monosomy X, B trisomy, C trisomy (10 trisomy), D trisomy, G trisomy, and triploidy. Some ocular abnormalities were identified which represented primarily a retardation of development, while other findings represented dysgenesis of ocular structures. The spectrum of ocular abnormalities included cyclopia, microphthalmia, cataract, staphyloma of the optic nerve, retinal dysplasia, and subluxation of the lens. Abnormalities of ocular development were thus seen in structures derived from surface ectoderm, neural ectoderm, and mesoderm in association with an abnormal karyotype.
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U2 - 10.1016/0002-9394(74)90074-9
DO - 10.1016/0002-9394(74)90074-9
M3 - Article
C2 - 4211187
AN - SCOPUS:0016139186
SN - 0002-9394
VL - 78
SP - 167
EP - 188
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -