Abstract
Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability - a common feature of many human cancers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23-34 |
| Number of pages | 12 |
| Journal | Nature Reviews Cancer |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2003 |
Funding
We apologize to those authors whose work is not cited owing to space constraints. A.D.D. is a Doris Duke Distinguished Clinical Scientist and is supported by National Institutes of Health grants. M.G. is supported by a National Institutes of Health grant.
| Funders |
|---|
| Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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