Abstract
On entry of viral DNA into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the DNA. In the case of herpes simplex virus 1, the first set of genes expressed after infection - are induced by a viral protein (αTIF or VP16). Expression of later (β,γ) genes in cells infected at low ratios of virus per cells requires a transcriptional activator (ICP4) that cannot block silencing and a protein, ICP0, hitherto characterized as a promiscuous transactivator. Recent studies indicate that ICP0 blocks silencing of viral DNA by dissociating HDACs 1 and 2 from the CoREST/REST repressor complex. HDACs 1/2 are phosphorylated and translocated to the nucleus. The findings have broad implications regarding silencing of the viral genome during latency and, potentially, the expression of genes encoded by other DNA viruses as well.
Original language | English (US) |
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Pages (from-to) | 1019-1021 |
Number of pages | 3 |
Journal | Cell Cycle |
Volume | 4 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2005 |
Externally published | Yes |
Keywords
- CoREST
- HDACs
- Herpes simplex virus 1
- ICP0
- Repressor complex
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology