The first 30 minutes in the life of a virus: UnREST in the nucleus

Bernard Roizman, Haidong Gu, Gail Mandel

Research output: Contribution to journalShort surveypeer-review

48 Scopus citations


On entry of viral DNA into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the DNA. In the case of herpes simplex virus 1, the first set of genes expressed after infection - are induced by a viral protein (αTIF or VP16). Expression of later (β,γ) genes in cells infected at low ratios of virus per cells requires a transcriptional activator (ICP4) that cannot block silencing and a protein, ICP0, hitherto characterized as a promiscuous transactivator. Recent studies indicate that ICP0 blocks silencing of viral DNA by dissociating HDACs 1 and 2 from the CoREST/REST repressor complex. HDACs 1/2 are phosphorylated and translocated to the nucleus. The findings have broad implications regarding silencing of the viral genome during latency and, potentially, the expression of genes encoded by other DNA viruses as well.

Original languageEnglish (US)
Pages (from-to)1019-1021
Number of pages3
JournalCell Cycle
Issue number8
StatePublished - Aug 2005
Externally publishedYes


  • CoREST
  • HDACs
  • Herpes simplex virus 1
  • ICP0
  • Repressor complex

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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