TY - JOUR
T1 - The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals
AU - Zeng, Dexing
AU - Zeglis, Brian M.
AU - Lewis, Jason S.
AU - Anderson, Carolyn J.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Click chemistry has become a ubiquitous chemical tool with applications in nearly all areas of modern chemistry, including drug discovery, bioconjugation, and nanoscience. Radiochemistry is no exception, as the canonical Cu(I)-catalyzed azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, inverse electron demand Diels-Alder reaction, and other types of bioorthogonal click ligations have had a significant impact on the synthesis and development of radiopharmaceuticals. This review will focus on recent applications of click chemistry ligations in the preparation of imaging agents for SPECT and PET, including small molecules, peptides, and proteins labeled with radionuclides such as 18F, 64Cu, 111In, and 99mTc.
AB - Click chemistry has become a ubiquitous chemical tool with applications in nearly all areas of modern chemistry, including drug discovery, bioconjugation, and nanoscience. Radiochemistry is no exception, as the canonical Cu(I)-catalyzed azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, inverse electron demand Diels-Alder reaction, and other types of bioorthogonal click ligations have had a significant impact on the synthesis and development of radiopharmaceuticals. This review will focus on recent applications of click chemistry ligations in the preparation of imaging agents for SPECT and PET, including small molecules, peptides, and proteins labeled with radionuclides such as 18F, 64Cu, 111In, and 99mTc.
KW - Click chemistry
KW - Radiochemistry
UR - http://www.scopus.com/inward/record.url?scp=84878642086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878642086&partnerID=8YFLogxK
U2 - 10.2967/jnumed.112.115550
DO - 10.2967/jnumed.112.115550
M3 - Review article
C2 - 23616581
AN - SCOPUS:84878642086
SN - 0161-5505
VL - 54
SP - 829
EP - 832
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 6
ER -