The growth hormone cascade and its role in mammalian growth

Ron G. Rosenfeld, Vivian Hwa

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


The myriad actions of growth hormone (GH) are still incompletely understood, despite decades of research. Although it is a major regulator of post-natal growth in mammals, much of its effects on skeletal growth are recognized to be mediated indirectly, through the stimulation of production of insulin-like growth factor (IGF)-I, as well as some of the major serum carrier proteins for IGF-I and -II, such as IGF-binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS). The regulation of IGF-I production by GH appears to be mediated entirely by signalling through the Janus kinase (JAK) 2 pathway, via the phosphorylation of the transcription factor, signal transducer and activator of transcription (STAT) 5b. GH also signals, however, through additional pathways that are likely to be critical to the metabolic actions of GH.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalHormone Research
Issue numberSUPPL. 2
StatePublished - Apr 2009
Externally publishedYes


  • Growth hormone
  • Insulin-like growth factor (IGF)
  • JAK2
  • Signal transducer and activator of transcription (STAT)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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