Abstract
The advent of directed gene-editing technologies now over 10 years ago ushered in a new era of precision medicine wherein specific disease-causing mutations can be corrected. In parallel with developing new gene-editing platforms, optimizing their efficiency and delivery has been remarkable. With their development, there has been interest in using gene-editing systems for correcting disease mutations in differentiated somatic cells ex vivo or in vivo or for germline gene editing in gametes or 1-cell embryos to potentially limit genetic diseases in the offspring and in future generations. This review details the development and history of the current gene-editing systems and the advantages and challenges in their use for somatic cell and germline gene editing.
Original language | English (US) |
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Pages (from-to) | 528-538 |
Number of pages | 11 |
Journal | Fertility and sterility |
Volume | 120 |
Issue number | 3P1 |
DOIs | |
State | Published - Sep 2023 |
Keywords
- CRISPR
- gene editing
- precision medicine
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology