TY - JOUR
T1 - The ‘Hot Cross Bun’ Sign Is Not Always Multiple System Atrophy
T2 - Etiologies of 11 Cases
AU - Way, Christopher
AU - Pettersson, David
AU - Hiller, Amie
N1 - Publisher Copyright:
© 2019, Korean Movement Disorder Society. All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - Objective To clarify the specificity of the ‘hot cross bun’ sign (HCBS) for multiple system atrophy (MSA) in adult cerebellar ataxia or parkinsonism. Methods The radiologic information systems at an academic center and affiliated veterans’ hospital were queried using the keywords ‘hot cross bun,’ ‘pontocerebellar,’ ‘cruciate,’ ‘cruciform,’ ‘MSA,’ ‘multiple system atrophy,’ and ‘multisystem atrophy.’ Scans were reviewed by a neurologist and neuroradiologist to identify the HCBS. Subjects with the HCBS were reviewed by 2 neurologists to identify the most likely etiology of the patient’s neurologic symptoms. Results Eleven cases were identified. Etiologies included MSA (4 probable, 2 possible), hereditary cerebellar ataxia (3/11), probable dementia with Lewy bodies (1/11), and uncertain despite autopsy (1/11). Conclusion MSA was the most common etiology. However, 5 of the 11 patients did not have MSA. The most common alternate etiology was an undefined hereditary cerebellar ataxia (3/11).
AB - Objective To clarify the specificity of the ‘hot cross bun’ sign (HCBS) for multiple system atrophy (MSA) in adult cerebellar ataxia or parkinsonism. Methods The radiologic information systems at an academic center and affiliated veterans’ hospital were queried using the keywords ‘hot cross bun,’ ‘pontocerebellar,’ ‘cruciate,’ ‘cruciform,’ ‘MSA,’ ‘multiple system atrophy,’ and ‘multisystem atrophy.’ Scans were reviewed by a neurologist and neuroradiologist to identify the HCBS. Subjects with the HCBS were reviewed by 2 neurologists to identify the most likely etiology of the patient’s neurologic symptoms. Results Eleven cases were identified. Etiologies included MSA (4 probable, 2 possible), hereditary cerebellar ataxia (3/11), probable dementia with Lewy bodies (1/11), and uncertain despite autopsy (1/11). Conclusion MSA was the most common etiology. However, 5 of the 11 patients did not have MSA. The most common alternate etiology was an undefined hereditary cerebellar ataxia (3/11).
KW - Multiple system atrophy
KW - cerebellar ataxia
KW - magnetic resonance imaging
KW - olivopontocerebellar atrophy
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U2 - 10.14802/jmd.18031
DO - 10.14802/jmd.18031
M3 - Article
AN - SCOPUS:85068105451
SN - 2005-940X
VL - 12
SP - 27
EP - 30
JO - Journal of Movement Disorders
JF - Journal of Movement Disorders
IS - 1
ER -