The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Andrew G. Nicholson; Frank C. Detterbeck; Mirella Marino; Jhingook Kim; Kelly Stratton; Dorothy Giroux; Hisao Asamura; John Crowley; Conrad Falkson; Pier Luigi Filosso; Giuseppe Giaccone; James Huang; Kazuya Kondo; Marco Lucchi; Edith M. Marom; Meinoshin Okumura; Enrico Ruffini; Paul Van Schil; Peter Goldstraw; Ramón Rami-Porta; David Ball; David Beer; Ricardo Beyruti; Vanessa Bolejack; Kari Chansky; Wilfried Ernst Erich Eberhardt; John Edwards; Françoise Galateau-Sallé; Fergus Gleeson; Patti Groome; Catherine Kennedy; Laura Kingsbury; Young Tae Kim; Haruhiko Kondo; Mark Krasnik; Kaoru Kubota; Antoon Lerut; Gustavo Lyons; Jan Van Meerbeeck; Alan Mitchell; Takashi Nakano; Anna Nowak; Michael Peake; Thomas Rice; Kenneth Rosenzweig; Valerie Rusch; Nagahiro Saijo; Jean Paul Sculier; Lynn Shemanski; Kenji Suzuki; Yuji Tachimori; Charles F. Thomas; William Travis; Ming S. Tsao; Andrew Turrisi; Johan Vansteenkiste; Hirokazu Watanabe; Yi Long Wu; Paul Baas; Jeremy Erasmus; Seiki Hasegawa; Kouki Inai; Kemp Kernstine; Hedy Kindler; Lee Krug; Kristiaan Nackaerts; Harvey Pass; David Rice; Eugene Blackstone; S. Call Caja; U. Ahmad; F. Detterbeck; N. Girard; Seok Jin Haam; D. R. Gomez; Mi Kyung Bae; P. Ströbel; A. Marx; S. Saita; H. Wakelee; L. Bertolaccini; E. Vallieres; W. Scott; S. Su; B. Park; J. Marks; S. Khella; R. Shen; M. Rosenberg; V. Tomulescu; C. Foroulis; L. Lang-Lazdunski; Andrea Billè; J. G. Maessen; M. Keijzers; H. Van Veer; C. Wright; F. Facciolo; G. Palmieri; C. Buonerba; M. Ferguson; G. Marulli; P. Loehrer; M. Kalkat; K. Rohrberg; G. Daugaard; A. Toker; S. Erus; M. Kimmich; A. Brunelli; M. Refai; A. Nicholson; E. Lim; In Kyu Park; J. Wagner; B. Tieu; Wentao Fang; Jie Zhang; Zhentao Yu; Yongtao Han; Yin Li; Keneng Chen; Gang Chen; Kanji Nagai; Yoshitaka Fujii; Jun Nakajima; Norihiko Ikeda; Shuji Haraguchi; Takamasa Onuki; Ichiro Yoshino; Masanori Tsuchida; Shoji Takahashi; Kohei Yokoi; Masayuki Hanyuda; Hiroshi Niwa; Hiroshi Date; Yoshimasa Maniwa; Shinichiro Miyoshi; Akinori Iwasaki; Tatsuro Okamoto; Takeshi Nagayasu; Fumihiro Tanaka; Minoru Suzuki; Kazuo Yoshida; Yusuke Okuma; Hirotoshi Horio; Akihide Matsumura; Masahiko Higashiyama; Hiroshi Suehisa; Takuya Onuki; Yoshifumi Sano; Keishi Kondo; K. Al Kattan; R. Cerfolio; C. Gebitekin; D. Gomez De Antonio; K. H. Kernstine; N. Altorki; N. Novoa; M. Scarci; L. Voltolini; W. Weder; Wojciech Zurek; A. Arame; C. Casadio; P. Carbognani; G. Donati; S. Keshavjee; W. Klepetko; B. Moser; C. Lequaglie; Moishe Liberman; M. Mancuso; M. Nosotti; L. Spaggiari; P. A. Thomas; E. Rendina; F. Venuta; M. Anile; J. Schützner; G. Rocco

doi:10.1097/JTO.0000000000000303

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

Andrew G. Nicholson, Frank C. Detterbeck, Mirella Marino, Jhingook Kim, Kelly Stratton, Dorothy Giroux, Hisao Asamura, John Crowley, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, James Huang, Kazuya Kondo, Marco Lucchi, Edith M. Marom, Meinoshin Okumura, Enrico Ruffini, Paul Van Schil, Peter Goldstraw, Ramón Rami-PortaDavid Ball, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Fergus Gleeson, Patti Groome, Catherine Kennedy, Laura Kingsbury, Young Tae Kim, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Jan Van Meerbeeck, Alan Mitchell, Takashi Nakano, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Valerie Rusch, Nagahiro Saijo, Jean Paul Sculier, Lynn Shemanski, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Eugene Blackstone, S. Call Caja, U. Ahmad, F. Detterbeck, N. Girard, Seok Jin Haam, D. R. Gomez, Mi Kyung Bae, P. Ströbel, A. Marx, S. Saita, H. Wakelee, L. Bertolaccini, E. Vallieres, W. Scott, S. Su, B. Park, J. Marks, S. Khella, R. Shen, M. Rosenberg, V. Tomulescu, C. Foroulis, L. Lang-Lazdunski, Andrea Billè, J. G. Maessen, M. Keijzers, H. Van Veer, C. Wright, F. Facciolo, G. Palmieri, C. Buonerba, M. Ferguson, G. Marulli, P. Loehrer, M. Kalkat, K. Rohrberg, G. Daugaard, A. Toker, S. Erus, M. Kimmich, A. Brunelli, M. Refai, A. Nicholson, E. Lim, In Kyu Park, J. Wagner, B. Tieu, Wentao Fang, Jie Zhang, Zhentao Yu, Yongtao Han, Yin Li, Keneng Chen, Gang Chen, Kanji Nagai, Yoshitaka Fujii, Jun Nakajima, Norihiko Ikeda, Shuji Haraguchi, Takamasa Onuki, Ichiro Yoshino, Masanori Tsuchida, Shoji Takahashi, Kohei Yokoi, Masayuki Hanyuda, Hiroshi Niwa, Hiroshi Date, Yoshimasa Maniwa, Shinichiro Miyoshi, Akinori Iwasaki, Tatsuro Okamoto, Takeshi Nagayasu, Fumihiro Tanaka, Minoru Suzuki, Kazuo Yoshida, Yusuke Okuma, Hirotoshi Horio, Akihide Matsumura, Masahiko Higashiyama, Hiroshi Suehisa, Takuya Onuki, Yoshifumi Sano, Keishi Kondo, K. Al Kattan, R. Cerfolio, C. Gebitekin, D. Gomez De Antonio, K. H. Kernstine, N. Altorki, N. Novoa, M. Scarci, L. Voltolini, W. Weder, Wojciech Zurek, A. Arame, C. Casadio, P. Carbognani, G. Donati, S. Keshavjee, W. Klepetko, B. Moser, C. Lequaglie, Moishe Liberman, M. Mancuso, M. Nosotti, L. Spaggiari, P. A. Thomas, E. Rendina, F. Venuta, M. Anile, J. Schützner, G. Rocco

Surgery

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.

Original language	English (US)
Pages (from-to)	S73-S80
Journal	Journal of Thoracic Oncology
Volume	9
Issue number	9
DOIs	https://doi.org/10.1097/JTO.0000000000000303
State	Published - Jan 1 2014

Keywords

Prognosis
Stage classification
Staging
Thymic carcinoma
Thymoma

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine

Access to Document

10.1097/JTO.0000000000000303

Cite this

Nicholson, A. G., Detterbeck, F. C., Marino, M., Kim, J., Stratton, K., Giroux, D., Asamura, H., Crowley, J., Falkson, C., Filosso, P. L., Giaccone, G., Huang, J., Kondo, K., Lucchi, M., Marom, E. M., Okumura, M., Ruffini, E., Van Schil, P., Goldstraw, P., ... Rocco, G. (2014). The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors. Journal of Thoracic Oncology, 9(9), S73-S80. https://doi.org/10.1097/JTO.0000000000000303

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors. / Nicholson, Andrew G.; Detterbeck, Frank C.; Marino, Mirella et al.
In: Journal of Thoracic Oncology, Vol. 9, No. 9, 01.01.2014, p. S73-S80.

Research output: Contribution to journal › Article › peer-review

Nicholson, AG, Detterbeck, FC, Marino, M, Kim, J, Stratton, K, Giroux, D, Asamura, H, Crowley, J, Falkson, C, Filosso, PL, Giaccone, G, Huang, J, Kondo, K, Lucchi, M, Marom, EM, Okumura, M, Ruffini, E, Van Schil, P, Goldstraw, P, Rami-Porta, R, Ball, D, Beer, D, Beyruti, R, Bolejack, V, Chansky, K, Eberhardt, WEE, Edwards, J, Galateau-Sallé, F, Gleeson, F, Groome, P, Kennedy, C, Kingsbury, L, Kim, YT, Kondo, H, Krasnik, M, Kubota, K, Lerut, A, Lyons, G, Van Meerbeeck, J, Mitchell, A, Nakano, T, Nowak, A, Peake, M, Rice, T, Rosenzweig, K, Rusch, V, Saijo, N, Sculier, JP, Shemanski, L, Suzuki, K, Tachimori, Y, Thomas, CF, Travis, W, Tsao, MS, Turrisi, A, Vansteenkiste, J, Watanabe, H, Wu, YL, Baas, P, Erasmus, J, Hasegawa, S, Inai, K, Kernstine, K, Kindler, H, Krug, L, Nackaerts, K, Pass, H, Rice, D, Blackstone, E, Call Caja, S, Ahmad, U, Detterbeck, F, Girard, N, Haam, SJ, Gomez, DR, Bae, MK, Ströbel, P, Marx, A, Saita, S, Wakelee, H, Bertolaccini, L, Vallieres, E, Scott, W, Su, S, Park, B, Marks, J, Khella, S, Shen, R, Rosenberg, M, Tomulescu, V, Foroulis, C, Lang-Lazdunski, L, Billè, A, Maessen, JG, Keijzers, M, Van Veer, H, Wright, C, Facciolo, F, Palmieri, G, Buonerba, C, Ferguson, M, Marulli, G, Loehrer, P, Kalkat, M, Rohrberg, K, Daugaard, G, Toker, A, Erus, S, Kimmich, M, Brunelli, A, Refai, M, Nicholson, A, Lim, E, Park, IK, Wagner, J, Tieu, B, Fang, W, Zhang, J, Yu, Z, Han, Y, Li, Y, Chen, K, Chen, G, Nagai, K, Fujii, Y, Nakajima, J, Ikeda, N, Haraguchi, S, Onuki, T, Yoshino, I, Tsuchida, M, Takahashi, S, Yokoi, K, Hanyuda, M, Niwa, H, Date, H, Maniwa, Y, Miyoshi, S, Iwasaki, A, Okamoto, T, Nagayasu, T, Tanaka, F, Suzuki, M, Yoshida, K, Okuma, Y, Horio, H, Matsumura, A, Higashiyama, M, Suehisa, H, Onuki, T, Sano, Y, Kondo, K, Al Kattan, K, Cerfolio, R, Gebitekin, C, Gomez De Antonio, D, Kernstine, KH, Altorki, N, Novoa, N, Scarci, M, Voltolini, L, Weder, W, Zurek, W, Arame, A, Casadio, C, Carbognani, P, Donati, G, Keshavjee, S, Klepetko, W, Moser, B, Lequaglie, C, Liberman, M, Mancuso, M, Nosotti, M, Spaggiari, L, Thomas, PA, Rendina, E, Venuta, F, Anile, M, Schützner, J & Rocco, G 2014, 'The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors', Journal of Thoracic Oncology, vol. 9, no. 9, pp. S73-S80. https://doi.org/10.1097/JTO.0000000000000303

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title = "The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors",

abstract = "Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.",

keywords = "Prognosis, Stage classification, Staging, Thymic carcinoma, Thymoma",

author = "Nicholson, {Andrew G.} and Detterbeck, {Frank C.} and Mirella Marino and Jhingook Kim and Kelly Stratton and Dorothy Giroux and Hisao Asamura and John Crowley and Conrad Falkson and Filosso, {Pier Luigi} and Giuseppe Giaccone and James Huang and Kazuya Kondo and Marco Lucchi and Marom, {Edith M.} and Meinoshin Okumura and Enrico Ruffini and {Van Schil}, Paul and Peter Goldstraw and Ram{\'o}n Rami-Porta and David Ball and David Beer and Ricardo Beyruti and Vanessa Bolejack and Kari Chansky and Eberhardt, {Wilfried Ernst Erich} and John Edwards and Fran{\c c}oise Galateau-Sall{\'e} and Fergus Gleeson and Patti Groome and Catherine Kennedy and Laura Kingsbury and Kim, {Young Tae} and Haruhiko Kondo and Mark Krasnik and Kaoru Kubota and Antoon Lerut and Gustavo Lyons and {Van Meerbeeck}, Jan and Alan Mitchell and Takashi Nakano and Anna Nowak and Michael Peake and Thomas Rice and Kenneth Rosenzweig and Valerie Rusch and Nagahiro Saijo and Sculier, {Jean Paul} and Lynn Shemanski and Kenji Suzuki and Yuji Tachimori and Thomas, {Charles F.} and William Travis and Tsao, {Ming S.} and Andrew Turrisi and Johan Vansteenkiste and Hirokazu Watanabe and Wu, {Yi Long} and Paul Baas and Jeremy Erasmus and Seiki Hasegawa and Kouki Inai and Kemp Kernstine and Hedy Kindler and Lee Krug and Kristiaan Nackaerts and Harvey Pass and David Rice and Eugene Blackstone and {Call Caja}, S. and U. Ahmad and F. Detterbeck and N. Girard and Haam, {Seok Jin} and Gomez, {D. R.} and Bae, {Mi Kyung} and P. Str{\"o}bel and A. Marx and S. Saita and H. Wakelee and L. Bertolaccini and E. Vallieres and W. Scott and S. Su and B. Park and J. Marks and S. Khella and R. Shen and M. Rosenberg and V. Tomulescu and C. Foroulis and L. Lang-Lazdunski and Andrea Bill{\`e} and Maessen, {J. G.} and M. Keijzers and {Van Veer}, H. and C. Wright and F. Facciolo and G. Palmieri and C. Buonerba and M. Ferguson and G. Marulli and P. Loehrer and M. Kalkat and K. Rohrberg and G. Daugaard and A. Toker and S. Erus and M. Kimmich and A. Brunelli and M. Refai and A. Nicholson and E. Lim and Park, {In Kyu} and J. Wagner and B. Tieu and Wentao Fang and Jie Zhang and Zhentao Yu and Yongtao Han and Yin Li and Keneng Chen and Gang Chen and Kanji Nagai and Yoshitaka Fujii and Jun Nakajima and Norihiko Ikeda and Shuji Haraguchi and Takamasa Onuki and Ichiro Yoshino and Masanori Tsuchida and Shoji Takahashi and Kohei Yokoi and Masayuki Hanyuda and Hiroshi Niwa and Hiroshi Date and Yoshimasa Maniwa and Shinichiro Miyoshi and Akinori Iwasaki and Tatsuro Okamoto and Takeshi Nagayasu and Fumihiro Tanaka and Minoru Suzuki and Kazuo Yoshida and Yusuke Okuma and Hirotoshi Horio and Akihide Matsumura and Masahiko Higashiyama and Hiroshi Suehisa and Takuya Onuki and Yoshifumi Sano and Keishi Kondo and {Al Kattan}, K. and R. Cerfolio and C. Gebitekin and {Gomez De Antonio}, D. and Kernstine, {K. H.} and N. Altorki and N. Novoa and M. Scarci and L. Voltolini and W. Weder and Wojciech Zurek and A. Arame and C. Casadio and P. Carbognani and G. Donati and S. Keshavjee and W. Klepetko and B. Moser and C. Lequaglie and Moishe Liberman and M. Mancuso and M. Nosotti and L. Spaggiari and Thomas, {P. A.} and E. Rendina and F. Venuta and M. Anile and J. Sch{\"u}tzner and G. Rocco",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 by the International Association for the Study of Lung Cancer.",

year = "2014",

month = jan,

day = "1",

doi = "10.1097/JTO.0000000000000303",

language = "English (US)",

volume = "9",

pages = "S73--S80",

journal = "Journal of Thoracic Oncology",

issn = "1556-0864",

publisher = "International Association for the Study of Lung Cancer",

number = "9",

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TY - JOUR

T1 - The IASLC/ITMIG thymic epithelial tumors staging project

T2 - Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

AU - Nicholson, Andrew G.

AU - Detterbeck, Frank C.

AU - Marino, Mirella

AU - Kim, Jhingook

AU - Stratton, Kelly

AU - Giroux, Dorothy

AU - Asamura, Hisao

AU - Crowley, John

AU - Falkson, Conrad

AU - Filosso, Pier Luigi

AU - Giaccone, Giuseppe

AU - Huang, James

AU - Kondo, Kazuya

AU - Lucchi, Marco

AU - Marom, Edith M.

AU - Okumura, Meinoshin

AU - Ruffini, Enrico

AU - Van Schil, Paul

AU - Goldstraw, Peter

AU - Rami-Porta, Ramón

AU - Ball, David

AU - Beer, David

AU - Beyruti, Ricardo

AU - Bolejack, Vanessa

AU - Chansky, Kari

AU - Eberhardt, Wilfried Ernst Erich

AU - Edwards, John

AU - Galateau-Sallé, Françoise

AU - Gleeson, Fergus

AU - Groome, Patti

AU - Kennedy, Catherine

AU - Kingsbury, Laura

AU - Kim, Young Tae

AU - Kondo, Haruhiko

AU - Krasnik, Mark

AU - Kubota, Kaoru

AU - Lerut, Antoon

AU - Lyons, Gustavo

AU - Van Meerbeeck, Jan

AU - Mitchell, Alan

AU - Nakano, Takashi

AU - Nowak, Anna

AU - Peake, Michael

AU - Rice, Thomas

AU - Rosenzweig, Kenneth

AU - Rusch, Valerie

AU - Saijo, Nagahiro

AU - Sculier, Jean Paul

AU - Shemanski, Lynn

AU - Suzuki, Kenji

AU - Tachimori, Yuji

AU - Thomas, Charles F.

AU - Travis, William

AU - Tsao, Ming S.

AU - Turrisi, Andrew

AU - Vansteenkiste, Johan

AU - Watanabe, Hirokazu

AU - Wu, Yi Long

AU - Baas, Paul

AU - Erasmus, Jeremy

AU - Hasegawa, Seiki

AU - Inai, Kouki

AU - Kernstine, Kemp

AU - Kindler, Hedy

AU - Krug, Lee

AU - Nackaerts, Kristiaan

AU - Pass, Harvey

AU - Rice, David

AU - Blackstone, Eugene

AU - Call Caja, S.

AU - Ahmad, U.

AU - Detterbeck, F.

AU - Girard, N.

AU - Haam, Seok Jin

AU - Gomez, D. R.

AU - Bae, Mi Kyung

AU - Ströbel, P.

AU - Marx, A.

AU - Saita, S.

AU - Wakelee, H.

AU - Bertolaccini, L.

AU - Vallieres, E.

AU - Scott, W.

AU - Su, S.

AU - Park, B.

AU - Marks, J.

AU - Khella, S.

AU - Shen, R.

AU - Rosenberg, M.

AU - Tomulescu, V.

AU - Foroulis, C.

AU - Lang-Lazdunski, L.

AU - Billè, Andrea

AU - Maessen, J. G.

AU - Keijzers, M.

AU - Van Veer, H.

AU - Wright, C.

AU - Facciolo, F.

AU - Palmieri, G.

AU - Buonerba, C.

AU - Ferguson, M.

AU - Marulli, G.

AU - Loehrer, P.

AU - Kalkat, M.

AU - Rohrberg, K.

AU - Daugaard, G.

AU - Toker, A.

AU - Erus, S.

AU - Kimmich, M.

AU - Brunelli, A.

AU - Refai, M.

AU - Nicholson, A.

AU - Lim, E.

AU - Park, In Kyu

AU - Wagner, J.

AU - Tieu, B.

AU - Fang, Wentao

AU - Zhang, Jie

AU - Yu, Zhentao

AU - Han, Yongtao

AU - Li, Yin

AU - Chen, Keneng

AU - Chen, Gang

AU - Nagai, Kanji

AU - Fujii, Yoshitaka

AU - Nakajima, Jun

AU - Ikeda, Norihiko

AU - Haraguchi, Shuji

AU - Onuki, Takamasa

AU - Yoshino, Ichiro

AU - Tsuchida, Masanori

AU - Takahashi, Shoji

AU - Yokoi, Kohei

AU - Hanyuda, Masayuki

AU - Niwa, Hiroshi

AU - Date, Hiroshi

AU - Maniwa, Yoshimasa

AU - Miyoshi, Shinichiro

AU - Iwasaki, Akinori

AU - Okamoto, Tatsuro

AU - Nagayasu, Takeshi

AU - Tanaka, Fumihiro

AU - Suzuki, Minoru

AU - Yoshida, Kazuo

AU - Okuma, Yusuke

AU - Horio, Hirotoshi

AU - Matsumura, Akihide

AU - Higashiyama, Masahiko

AU - Suehisa, Hiroshi

AU - Onuki, Takuya

AU - Sano, Yoshifumi

AU - Kondo, Keishi

AU - Al Kattan, K.

AU - Cerfolio, R.

AU - Gebitekin, C.

AU - Gomez De Antonio, D.

AU - Kernstine, K. H.

AU - Altorki, N.

AU - Novoa, N.

AU - Scarci, M.

AU - Voltolini, L.

AU - Weder, W.

AU - Zurek, Wojciech

AU - Arame, A.

AU - Casadio, C.

AU - Carbognani, P.

AU - Donati, G.

AU - Keshavjee, S.

AU - Klepetko, W.

AU - Moser, B.

AU - Lequaglie, C.

AU - Liberman, Moishe

AU - Mancuso, M.

AU - Nosotti, M.

AU - Spaggiari, L.

AU - Thomas, P. A.

AU - Rendina, E.

AU - Venuta, F.

AU - Anile, M.

AU - Schützner, J.

AU - Rocco, G.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.

AB - Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.

KW - Prognosis

KW - Stage classification

KW - Staging

KW - Thymic carcinoma

KW - Thymoma

UR - http://www.scopus.com/inward/record.url?scp=84921747900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921747900&partnerID=8YFLogxK

U2 - 10.1097/JTO.0000000000000303

DO - 10.1097/JTO.0000000000000303

M3 - Article

C2 - 25396315

AN - SCOPUS:84921747900

SN - 1556-0864

VL - 9

SP - S73-S80

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

IS - 9

ER -

The IASLC/ITMIG thymic epithelial tumors staging project: Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors

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