THE INSULIN-LIKE GROWTH FACTOR I RECEPTOR: MOLECULAR BIOLOGY, HETEROGENEITY, AND REGULATION

Haim Werner; Michael Woloschak; Bethel Stannard; Zila Shen-Orr; Charles T. Roberts; Derek LeRoith

doi:10.1201/9781003574583-2

THE INSULIN-LIKE GROWTH FACTOR I RECEPTOR: MOLECULAR BIOLOGY, HETEROGENEITY, AND REGULATION

Haim Werner, Michael Woloschak, Bethel Stannard, Zila Shen-Orr, Charles T. Roberts, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Insulin-like growth factor I (IGF-I) exerts most of its biological actions by binding to a specific membrane-associated glycoprotein receptor. 1, 2 These biological actions, which are described in more detail in Chapter 10, include short-term, metabolic (insulin-like) effects as well as long-term, growth-promoting actions. These responses are the culmination of a chain of events which are initiated by the binding of the IGF-I ligand to the extracellular portion of the receptor. Allosteric changes in the receptor structure activate the cytoplasmic (tyrosine kinase-containing) domain of the molecule, resulting in the transduction of a signal through a mechanism which has not yet been clarified. 3, 4.

Original language	English (US)
Title of host publication	Insulin-Like Growth Factors
Subtitle of host publication	Molecular and Cellular Aspects
Publisher	CRC Press
Pages	17-47
Number of pages	31
ISBN (Electronic)	9781040294499
ISBN (Print)	9780849357121
DOIs	https://doi.org/10.1201/9781003574583-2
State	Published - Jan 1 2024
Externally published	Yes

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1201/9781003574583-2

Cite this

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THE INSULIN-LIKE GROWTH FACTOR I RECEPTOR: MOLECULAR BIOLOGY, HETEROGENEITY, AND REGULATION

Abstract

ASJC Scopus subject areas

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