The many faces of REST oversee epigenetic programming of neuronal genes

Nurit Ballas; Gail Mandel

doi:10.1016/j.conb.2005.08.015

The many faces of REST oversee epigenetic programming of neuronal genes

Nurit Ballas
, Gail Mandel

Research output: Contribution to journal › Review article › peer-review

361 Scopus citations

Abstract

Nervous system development relies on a complex signaling network to engineer the orderly transitions that lead to the acquisition of a neural cell fate. Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons. Concurrently, cells outside the nervous system acquire and maintain a non-neuronal fate that permanently excludes expression of neuronal genes. Studies of the transcriptional repressor REST, which regulates a large network of neuronal genes, provide a paradigm for elucidating the link between epigenetic mechanisms and neurogenesis. REST orchestrates a set of epigenetic modifications that are distinct between non-neuronal cells that give rise to neurons and those that are destined to remain as nervous system outsiders.

Original language	English (US)
Pages (from-to)	500-506
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.conb.2005.08.015
State	Published - Oct 2005
Externally published	Yes

Funding

The authors thank J Chenoweth IV and R Shiekhattar for permitting us to cite unpublished work, and J Speh for help with the figures. We apologize for omitted citations due to space limitations. G Mandel is an investigator of the Howard Hughes Medical Institute. We acknowledge support from a National Institutes of Health grant to G Mandel.

Funders
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2005.08.015

Cite this

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title = "The many faces of REST oversee epigenetic programming of neuronal genes",

abstract = "Nervous system development relies on a complex signaling network to engineer the orderly transitions that lead to the acquisition of a neural cell fate. Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons. Concurrently, cells outside the nervous system acquire and maintain a non-neuronal fate that permanently excludes expression of neuronal genes. Studies of the transcriptional repressor REST, which regulates a large network of neuronal genes, provide a paradigm for elucidating the link between epigenetic mechanisms and neurogenesis. REST orchestrates a set of epigenetic modifications that are distinct between non-neuronal cells that give rise to neurons and those that are destined to remain as nervous system outsiders.",

author = "Nurit Ballas and Gail Mandel",

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AB - Nervous system development relies on a complex signaling network to engineer the orderly transitions that lead to the acquisition of a neural cell fate. Progression from the non-neuronal pluripotent stem cell to a restricted neural lineage is characterized by distinct patterns of gene expression, particularly the restriction of neuronal gene expression to neurons. Concurrently, cells outside the nervous system acquire and maintain a non-neuronal fate that permanently excludes expression of neuronal genes. Studies of the transcriptional repressor REST, which regulates a large network of neuronal genes, provide a paradigm for elucidating the link between epigenetic mechanisms and neurogenesis. REST orchestrates a set of epigenetic modifications that are distinct between non-neuronal cells that give rise to neurons and those that are destined to remain as nervous system outsiders.

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The many faces of REST oversee epigenetic programming of neuronal genes

Abstract

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ASJC Scopus subject areas

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