The many important facets of T-cell repertoire diversity

Janko Nikolich-Žugich, Mark K. Slifka, Ilhem Messaoudi

Research output: Contribution to journalReview articlepeer-review

485 Scopus citations


In the thymus, a diverse and polymorphic T-cell repertoire is generated by random recombination of discrete T-cell receptor (TCR)-αβ gene segments. This repertoire is then shaped by intrathymic selection events to generate a peripheral T-cell pool of self-MHC restricted, non-autoaggressive T cells. It has long been postulated that some optimal level of TCR diversity allows efficient protection against pathogens. This article focuses on several recent advances that address the required diversity for the generation of an optimal immune response.

Original languageEnglish (US)
Pages (from-to)123-132
Number of pages10
JournalNature Reviews Immunology
Issue number2
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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