TY - JOUR
T1 - The Missing Link in Correlates of Protective Tuberculosis Immunity
T2 - Recognizing the Infected Cell
AU - Lewinsohn, David Michael
AU - Lewinsohn, Deborah Anne
N1 - Publisher Copyright:
Copyright © 2022 Lewinsohn and Lewinsohn.
PY - 2022/4/12
Y1 - 2022/4/12
N2 - For most vaccination studies, the assessment of vaccine-induced CD4+ and CD8+ T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4+ and CD8+ T cells to recognize the Mtb-infected cell.
AB - For most vaccination studies, the assessment of vaccine-induced CD4+ and CD8+ T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4+ and CD8+ T cells to recognize the Mtb-infected cell.
KW - CD4/CD8 lymphocytes + +
KW - MTB
KW - cytolytic
KW - granuloma
KW - intracellular infection
UR - http://www.scopus.com/inward/record.url?scp=85128819333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85128819333&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.869057
DO - 10.3389/fimmu.2022.869057
M3 - Review article
C2 - 35493495
AN - SCOPUS:85128819333
SN - 1664-3224
VL - 13
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 869057
ER -