The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell

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2 Scopus citations

Abstract

For most vaccination studies, the assessment of vaccine-induced CD4+ and CD8+ T cells has relied upon the measurement of antigen-specific polyfunctional cells, typically using recombinant antigen or peptide pools. However, this approach leaves open the question as to whether or not these cells are responsive to the Mtb-infected cell within the context of Mtb infection and hence leaves open the possibility that a key parameter of vaccine immunogenicity may be overlooked. In this review, we discuss the case that these measurements almost certainly over-estimate the capacity of both CD4+ and CD8+ T cells to recognize the Mtb-infected cell.

Original languageEnglish (US)
Article number869057
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Apr 12 2022

Keywords

  • CD4/CD8 lymphocytes + +
  • MTB
  • cytolytic
  • granuloma
  • intracellular infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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