The myoD gene family: Nodal point during specification of the muscle cell lineage

Harold Weintraub; Robert Davis; Stephen Tapscott; Matthew Thayer; Michael Krause; Robert Benezra; T. Keith Blackwell; David Turner; Ralph Rupp; Stanley Hollenberg; Yuan Zhuang; Andrew Lassar

The myoD gene family: Nodal point during specification of the muscle cell lineage

Harold Weintraub, Robert Davis, Stephen Tapscott, Matthew Thayer, Michael Krause, Robert Benezra, T. Keith Blackwell, David Turner, Ralph Rupp, Stanley Hollenberg, Yuan Zhuang, Andrew Lassar

Research output: Contribution to journal › Article › peer-review

1447 Scopus citations

Abstract

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loophelix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

Original language	English (US)
Pages (from-to)	761-766
Number of pages	6
Journal	Science
Volume	251
Issue number	4995
State	Published - Feb 15 1991
Externally published	Yes

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Cite this

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AU - Weintraub, Harold

AU - Davis, Robert

AU - Tapscott, Stephen

AU - Thayer, Matthew

AU - Krause, Michael

AU - Benezra, Robert

AU - Blackwell, T. Keith

AU - Turner, David

AU - Rupp, Ralph

AU - Hollenberg, Stanley

AU - Zhuang, Yuan

AU - Lassar, Andrew

PY - 1991/2/15

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AB - The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loophelix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

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The myoD gene family: Nodal point during specification of the muscle cell lineage

Abstract

ASJC Scopus subject areas

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