The natural history of air-flow obstruction in PiZ emphysema

A. S. Buist, B. Burrows, S. Eriksson, C. Mittman, M. Wu

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


From the data presented, it would appear that PiZ subjects who develop clinically significant airflow limitation go through a phase of their disease in which there is a relatively high rate of functional decline. This is encouraging in regard to the feasibility of a trial of antiprotease therapy. It suggests that beneficial effects of such therapy could be demonstrated by showing a reduction in the rate of loss of function in subjects properly selected for such a clinical trial.

Original languageEnglish (US)
Pages (from-to)S43-S45
JournalAmerican Review of Respiratory Disease
Issue number2
StatePublished - 1983

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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