Abstract
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
Original language | English (US) |
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Article number | e2407246121 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 121 |
Issue number | 42 |
DOIs | |
State | Published - Oct 15 2024 |
Keywords
- MRI
- cerebrospinal fluid
- glymphatic
- perivascular space
ASJC Scopus subject areas
- General