The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report

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Abstract

The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.

Original languageEnglish (US)
Article numbere2407246121
JournalProceedings of the National Academy of Sciences of the United States of America
Volume121
Issue number42
DOIs
StatePublished - Oct 15 2024

Keywords

  • MRI
  • cerebrospinal fluid
  • glymphatic
  • perivascular space

ASJC Scopus subject areas

  • General

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