The Prevalence of Metabolic and Endocrine Disturbances on Fracture Nonunion

Patrick F. Bergin, David L. Rothberg, Clay A. Spitler, Bopha Chrea, Daniel T. Miles, Ugur Yener, Eldrin Bhanat, Hunter G. Frederiksen, Matt L. Graves

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: This study aims to determine the prevalence of metabolic disturbance in all fracture nonunion cases and identify the most common endocrine abnormalities seen using a simple screening algorithm. Methods: A retrospective review study was performed evaluating patients who underwent operative intervention for nonunion from January 2010 to December 2018 at 2 level-1 trauma centers. Preoperative laboratory values were recorded for a 9-test “nonunion panel.” A metabolic or endocrine abnormality, specifically an abnormality in the thyroid or parathyroid axis, was evaluated. Results: 42% of patients had an undiagnosed metabolic laboratory abnormality. When multiple tests were used, the rate of metabolic dysfunction was between 60% and 75%, depending on the definition of vitamin D insufficiency vs deficiency used. Conclusion: Results indicate a relatively high prevalence of metabolic disturbance in patients with nonunion and suggest metabolic screening for all nonunion patients not only those without a mechanical or infectious cause. Level of Evidence: IV, retrospective case series.

Original languageEnglish (US)
Pages (from-to)599-602
Number of pages4
JournalEndocrine Practice
Issue number6
StatePublished - Jun 2022


  • endocrine disorders
  • fracture nonunion
  • metabolic disorders

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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